Atrial natriuretic peptide
Also known as: ANF, ANP, Atrial natriuretic factor, Atriopeptin, Carperitide, hANP
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Summary
Endogenous cardiac hormone that regulates blood volume and pressure; synthetic analogs are used experimentally for acute heart‑failure and hypertensive crises.
Mechanism of Action
Binds natriuretic peptide receptor‑A (NPR‑A) → activates guanylyl cyclase → ↑cGMP → vasodilation, natriuresis, inhibition of renin‑angiotensin‑aldosterone system
Routes of Administration
Goals & Uses
- Diuretic‑resistant edemaNephrologyLow
- Pulmonary hypertension managementCardiovascularLow
- Acute decompensated heart failureCardiovascularModerate
- Blood pressure reductionCardiovascularModerate
- Natriuresis and diuresisFluid/electrolyte ManagementHigh
- Acute decompensated heart failure treatmentCardiovascularModerate
- Renal protection in acute kidney injuryRenalLow
- Hypertensive emergencyCardiologyLow
- RAAS suppressionCardiovascular/EndocrineHigh
Contraindications
- Severe aortic or mitral stenosisCardiovascularModerate
- Constrictive pericarditis / pericardial tamponadeCardiovascularModerate
- Cardiogenic shockCardiovascularHigh
- Aortic stenosis (critical)CardiacModerate
- Hypersensitivity to ANP or carperitideImmunologicalHigh
- HypotensionCardiovascularHigh
- Severe hypotension (SBP <90 mmHg)HemodynamicHigh
Adverse Effects
- Tachycardia (reflex)CardiovascularUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- Dizziness / lightheadednessNeurologicCommon
- HypotensionCardiovascularCommonLow blood pressure
- Renal dysfunctionRenalRare
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- Renal dysfunction (↑creatinine)RenalRare
Drug Interactions
- Sodium‑glucose cotransporter‑2 (SGLT2) inhibitorsLow
- Phosphodiesterase inhibitors (e.g., sildenafil)High
- Antihypertensive agentsModerate
- ACE inhibitors / ARBsModerate
- NSAIDsModerateMay increase renal risk in susceptible patients
- ACE inhibitorsModerate
- DiureticsModerateMay worsen dehydration or electrolyte imbalance
Population Constraints
- PregnancyReproductive SafetyRelative
- Hepatic impairmentOrgan FunctionRelative
- Severe renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Pediatric (<1 yr)AgeRelative
- Elderly patientsAgeRelative
Regulatory Status
- European UnionUnapprovedANP not marketed; investigational use only.
- United StatesUnapprovedNo FDA‑approved ANP product; recombinant B‑type peptide (nesiritide) is approved.
- United KingdomUnapprovedNot approved by MHRA as a therapeutic; research use only.
Carperitide (synthetic human ANP) is approved in Japan for acute heart failure. In the US and EU, native ANP is not approved as a therapeutic agent; it is primarily used in research settings. Nesiritide (BNP) is the approved natriuretic peptide therapy in the US for acute decompensated heart failure.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Atrial natriuretic peptide?
Endogenous cardiac hormone that regulates blood volume and pressure; synthetic analogs are used experimentally for acute heart‑failure and hypertensive crises.
What is Atrial natriuretic peptide used for?
Atrial natriuretic peptide is educationally associated with: Diuretic‑resistant edema, Pulmonary hypertension management, Acute decompensated heart failure, Blood pressure reduction, Natriuresis and diuresis, Acute decompensated heart failure treatment, Renal protection in acute kidney injury, Hypertensive emergency, RAAS suppression. Educational only — not medical advice.
How is Atrial natriuretic peptide administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of Atrial natriuretic peptide?
Reported adverse effects include: Tachycardia (reflex), Headache, Dizziness / lightheadedness, Hypotension, Renal dysfunction, Nausea, Renal dysfunction (↑creatinine). This list is not exhaustive — consult a qualified clinician.
Who should avoid Atrial natriuretic peptide?
Recorded contraindications: Severe aortic or mitral stenosis, Constrictive pericarditis / pericardial tamponade, Cardiogenic shock, Aortic stenosis (critical), Hypersensitivity to ANP or carperitide, Hypotension, Severe hypotension (SBP <90 mmHg). Consult a qualified clinician before use.