Bleomycin A6
Also known as: Bleomycin A6, Bleomycin A6 (Pinyangmycin), Bleomycin sulfate, BLM A6, BLM-A6, Boanmycin, Pingyangmycin
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Summary
Bleomycin A6 is a component of the bleomycin mixture used as an antineoplastic agent; it induces DNA cleavage leading to tumor cell death.
Mechanism of Action
Binds Fe2+ and DNA, generating free radicals that cause DNA strand breaks and inhibit replication
Routes of Administration
Goals & Uses
- Hodgkin lymphoma treatmentOncologyHigh
- Lymphoma treatmentOncologyModerate
- Testicular carcinoma treatmentOncologyModerate
- Hemangioma treatmentDermatology/PediatricsLow
- Squamous cell carcinoma treatmentOncologyModerate
- Vascular malformation sclerotherapyInterventional RadiologyModerate
- Testicular cancer adjuvant therapyOncologyHigh
Contraindications
- Severely impaired renal functionRenalHigh
- Hypersensitivity to bleomycin compoundsImmunologicHigh
- Known hypersensitivity to bleomycinImmuneHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Pulmonary fibrosis or severe lung diseasePulmonaryHigh
- Pulmonary fibrosisRespiratoryHigh
Adverse Effects
- Oral mucositis / stomatitisMucosalUncommon
- Fever and chillsConstitutionalCommon
- Nausea and vomitingGastrointestinalUncommon
- Anaphylactoid reactionImmunologicRare
- MucositisGastrointestinal / MucosalUncommon
- Skin hyperpigmentationDermatologicCommon
- Pulmonary toxicity / pulmonary fibrosisPulmonaryUncommon
- Pulmonary toxicityRespiratoryCommon
- Mucocutaneous toxicity (skin thickening, hyperpigmentation, alopecia)DermatologicCommon
Drug Interactions
- Supplemental oxygen (high FiO2)High
- G-CSF / GM-CSFModerate
- CisplatinHigh
- Vinca alkaloids (vincristine, vinblastine)Low
- High inspired oxygen concentrationsHigh
- Other DNA‑damaging agents (e.g., cisplatin)Moderate
Population Constraints
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Pregnant or breastfeeding womenReproductiveAbsolute
- Patients with renal impairmentOrgan ImpairmentRelative
- Elderly patientsAgeRelative
- Elderly patients (≥65 years)Age RelatedRelative
Regulatory Status
- European UnionApprovedApproved: Hodgkin lymphoma, Testicular cancerEMA approval with similar restrictions on pulmonary toxicity.
- United StatesApprovedApproved: Hodgkin lymphoma, Testicular cancer, Squamous cell carcinoma of head and neckFDA‑approved as bleomycin sulfate for IV/IM administration.
- United KingdomUnapprovedMHRA approvals cover bleomycin sulfate (A2/B2); Bleomycin A6 not separately licensed.
Approved for Hodgkin lymphoma, testicular cancer, squamous cell carcinoma of the head and neck; dosing limited by pulmonary toxicity risk.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Bleomycin A6?
Bleomycin A6 is a component of the bleomycin mixture used as an antineoplastic agent; it induces DNA cleavage leading to tumor cell death.
What is Bleomycin A6 used for?
Bleomycin A6 is educationally associated with: Hodgkin lymphoma treatment, Lymphoma treatment, Testicular carcinoma treatment, Hemangioma treatment, Squamous cell carcinoma treatment, Vascular malformation sclerotherapy, Testicular cancer adjuvant therapy. Educational only — not medical advice.
How is Bleomycin A6 administered?
Recorded routes of administration: Intralesional, Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Bleomycin A6?
Reported adverse effects include: Oral mucositis / stomatitis, Fever and chills, Nausea and vomiting, Anaphylactoid reaction, Mucositis, Skin hyperpigmentation, Pulmonary toxicity / pulmonary fibrosis, Pulmonary toxicity, Mucocutaneous toxicity (skin thickening, hyperpigmentation, alopecia). This list is not exhaustive — consult a qualified clinician.
Who should avoid Bleomycin A6?
Recorded contraindications: Severely impaired renal function, Hypersensitivity to bleomycin compounds, Known hypersensitivity to bleomycin, Pregnancy, Pulmonary fibrosis or severe lung disease, Pulmonary fibrosis. Consult a qualified clinician before use.