Ceruletide
Also known as: Caerulein, Caerulein analog, Cerulein, Ceruletide, Ceruletide acetate, CRL, FI-6934, Takus
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Summary
Ceruletide is a synthetic decapeptide analog of cholecystokinin used primarily as a diagnostic agent to stimulate gallbladder contraction and pancreatic secretion, and as a research tool for studying CCK receptors.
Mechanism of Action
Agonist of CCK-A (CCK1) receptors, stimulating pancreatic enzyme secretion, gallbladder contraction, gastric acid secretion, and smooth muscle activity.
Routes of Administration
Goals & Uses
- Pancreatic secretion stimulationResearchHigh
- Treatment of paralytic ileusTherapeuticModerate
- Pancreatic exocrine function testingDiagnosticHigh
- CCK receptor pharmacologyResearchHigh
- Induction of experimental pancreatitisResearchHigh
- Diagnostic gallbladder stimulationDiagnosticModerate
- Appetite suppression researchResearchLow
- Potential constipation therapyTherapeuticLow
- Gallbladder function testingDiagnosticHigh
Contraindications
- Known hypersensitivity to ceruletideAllergyHigh
- Hypersensitivity to ceruletideImmunologicHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Severe intestinal obstructionGastrointestinalModerate
- Biliary obstructionBiliaryHigh
- Acute pancreatitisGastrointestinalHigh
- Pancreatic duct obstructionGastrointestinalHigh
- Acute cholecystitisGastrointestinalHigh
Adverse Effects
- Abdominal cramping/painGastrointestinalCommon
- Hypersensitivity/anaphylaxisImmunologicalRare
- HypotensionCardiovascularRareLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- Nausea and vomitingGastrointestinalCommon
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- Acute pancreatitisGastrointestinalRare
- DiarrheaGastrointestinalUncommonLoose or frequent stools
- Abdominal painGastrointestinalCommonPain or discomfort in the abdomen
Drug Interactions
- CCK receptor antagonists (e.g., lorglumide)High
- Other secretagogues (e.g., secretin)Moderate
- AtropineModerate
- Anticholinergic agentsModerate
- Opioid analgesicsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
- PediatricsAgeRelative
- Patients with known gallstonesGastrointestinalRelative
Regulatory Status
- European UnionUnapprovedNot authorized for clinical use
- United StatesUnapprovedAvailable only for investigational or research use
- United KingdomUnapprovedClassed as a research chemical
Not approved for therapeutic use in the United States or European Union; available only for investigational or research purposes.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Ceruletide?
Ceruletide is a synthetic decapeptide analog of cholecystokinin used primarily as a diagnostic agent to stimulate gallbladder contraction and pancreatic secretion, and as a research tool for studying CCK receptors.
What is Ceruletide used for?
Ceruletide is educationally associated with: Pancreatic secretion stimulation, Treatment of paralytic ileus, Pancreatic exocrine function testing, CCK receptor pharmacology, Induction of experimental pancreatitis, Diagnostic gallbladder stimulation, Appetite suppression research, Potential constipation therapy, Gallbladder function testing. Educational only — not medical advice.
How is Ceruletide administered?
Recorded routes of administration: Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Ceruletide?
Reported adverse effects include: Abdominal cramping/pain, Hypersensitivity/anaphylaxis, Hypotension, Flushing, Nausea and vomiting, Nausea, Acute pancreatitis, Diarrhea, Abdominal pain. This list is not exhaustive — consult a qualified clinician.
Who should avoid Ceruletide?
Recorded contraindications: Known hypersensitivity to ceruletide, Hypersensitivity to ceruletide, Pregnancy, Severe intestinal obstruction, Biliary obstruction, Acute pancreatitis, Pancreatic duct obstruction, Acute cholecystitis. Consult a qualified clinician before use.