Corticorelin
Also known as: Acthrel, Corticorelin acetate, corticorelin ovine triflutate, Cortrosyn, CRF (corticotropin-releasing factor), CRH, hCRH synthetic analog, oCRH
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Summary
Synthetic 41‑amino‑acid peptide (corticorelin acetate) used as a diagnostic agent to assess pituitary ACTH reserve in adrenal insufficiency testing.
Mechanism of Action
Agonist at CRH receptors (CRHR1) on pituitary corticotrophs, stimulating ACTH release and downstream cortisol production
Routes of Administration
Goals & Uses
- Peritumoral brain edema reductionTherapeuticLow
- Differential diagnosis of Cushing's syndromeDiagnosticHigh
- Evaluation of pituitary functionDiagnosticHigh
- Evaluation of hypothalamic-pituitary-adrenal (HPA) axis functionDiagnosticModerate
- Diagnostic assessment of ACTH reserveDiagnosticHigh
Contraindications
- Hypersensitivity to corticorelin or any componentAllergyHigh
- Administration with heparin or heparin-containing solutionsDrug InteractionHigh
- Hypersensitivity to corticorelin or excipientsAllergyHigh
- Acute coronary syndromeCardiovascularModerate
Adverse Effects
- Dyspnea/shortness of breathRespiratoryUncommon
- AnaphylaxisImmunologicRareSevere life-threatening allergic reaction
- Injection site reactionsLocalUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- HypotensionCardiovascularUncommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
Drug Interactions
- HeparinHigh
- GlucocorticoidsLow
- Glucocorticoids (exogenous)Moderate
- MetyraponeLow
- Beta‑adrenergic agonistsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Patients with cardiovascular diseaseComorbidityRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionUnapprovedNot authorized for clinical use in the EU.
- United StatesApprovedApproved: Diagnostic testing of ACTH reserveMarketed as Cortrosyn.
- United KingdomUnapprovedNo marketing authorization.
Approved in the United States for diagnostic use (Cortrosyn). Not indicated for therapeutic treatment of disease.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Corticorelin?
Synthetic 41‑amino‑acid peptide (corticorelin acetate) used as a diagnostic agent to assess pituitary ACTH reserve in adrenal insufficiency testing.
What is Corticorelin used for?
Corticorelin is educationally associated with: Peritumoral brain edema reduction, Differential diagnosis of Cushing's syndrome, Evaluation of pituitary function, Evaluation of hypothalamic-pituitary-adrenal (HPA) axis function, Diagnostic assessment of ACTH reserve. Educational only — not medical advice.
How is Corticorelin administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of Corticorelin?
Reported adverse effects include: Dyspnea/shortness of breath, Anaphylaxis, Injection site reactions, Headache, Hypotension, Flushing, Tachycardia, Nausea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Corticorelin?
Recorded contraindications: Hypersensitivity to corticorelin or any component, Administration with heparin or heparin-containing solutions, Hypersensitivity to corticorelin or excipients, Acute coronary syndrome. Consult a qualified clinician before use.