Corticorelin ovine triflutate
Also known as: ACTH (1-24), Acthrel, corticorelin, Cortrosyn, Cosyntropin, CRF (ovine), oCRH, ovine CRH, Tetracosactide
Source Corticorelin ovine triflutate at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Affiliate link: we earn a commission on purchases made through this link, at no extra cost to you.
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Corticorelin ovine triflutate (Acthrel) is a synthetic form of ovine corticotropin-releasing hormone used as a diagnostic agent to distinguish pituitary-dependent Cushing's disease from ectopic ACTH syndrome and adrenal tumors. It stimulates pituitary ACTH secretion and is administered as an intravenous injection for the differential diagnosis of ACTH-dependent hypercortisolism.
Mechanism of Action
Synthetic ovine corticotropin-releasing hormone (oCRH) that binds to CRH receptors on pituitary corticotroph cells, stimulating the synthesis and release of adrenocorticotropic hormone (ACTH) and beta-endorphin. Used diagnostically to differentiate the source of excess ACTH production.
Routes of Administration
Goals & Uses
- ACTH stimulation testDiagnosticHigh
- Assessment of adrenal insufficiencyDiagnosticHigh
- Differential diagnosis of Cushing's syndromeDiagnosticHigh
- Inferior petrosal sinus sampling (IPSS) adjunctDiagnosticHigh
- Evaluation of hypothalamic-pituitary-adrenal (HPA) axis functionDiagnosticModerate
Contraindications
- Concurrent heparin administrationDrug InteractionModerate
- Hypersensitivity to cosyntropin or any component of the formulationAllergyHigh
- Hypersensitivity to corticorelin or ovine proteinsAllergy/ImmunologyHigh
Adverse Effects
- AnaphylaxisImmunologicRareSevere life-threatening allergic reaction
- Facial flushingCardiovascular/DermatologicCommon
- Injection site reactionsLocalUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- HypotensionCardiovascularUncommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- DyspneaRespiratoryRareShortness of breath
Drug Interactions
- HeparinModerate
- KetoconazoleModerate
- Exogenous glucocorticoidsModerate
- Glucocorticoids (exogenous)Moderate
- MetyraponeLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- ElderlyAgeRelative
- Patients with known allergy to ovine proteinsAllergyAbsolute
Regulatory Status
- European UnionApprovedApproved: ACTH stimulation testEMA‑approved under similar indications.
- United StatesApprovedApproved: ACTH stimulation testFDA‑approved as Cosyntropin for diagnostic use.
- United KingdomApprovedApproved: ACTH stimulation testMHRA‑approved.
Approved for diagnostic evaluation of adrenal insufficiency and for assessment of cortisol reserve.
Evidence & Sources
- Journal ArticleLow1994-01-01T00:00:00.000000Z
Frequently Asked Questions
What is Corticorelin ovine triflutate?
Corticorelin ovine triflutate (Acthrel) is a synthetic form of ovine corticotropin-releasing hormone used as a diagnostic agent to distinguish pituitary-dependent Cushing's disease from ectopic ACTH syndrome and adrenal tumors. It stimulates pituitary ACTH secretion and is administered as an intravenous injection for the differential diagnosis of ACTH-dependent hypercortisolism.
What is Corticorelin ovine triflutate used for?
Corticorelin ovine triflutate is educationally associated with: ACTH stimulation test, Assessment of adrenal insufficiency, Differential diagnosis of Cushing's syndrome, Inferior petrosal sinus sampling (IPSS) adjunct, Evaluation of hypothalamic-pituitary-adrenal (HPA) axis function. Educational only — not medical advice.
How is Corticorelin ovine triflutate administered?
Recorded routes of administration: Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Corticorelin ovine triflutate?
Reported adverse effects include: Anaphylaxis, Facial flushing, Injection site reactions, Headache, Hypotension, Flushing, Tachycardia, Nausea, Dyspnea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Corticorelin ovine triflutate?
Recorded contraindications: Concurrent heparin administration, Hypersensitivity to cosyntropin or any component of the formulation, Hypersensitivity to corticorelin or ovine proteins. Consult a qualified clinician before use.