Corticorelin ovine triflutate
Also known as: ACTH (1-24), Acthrel, corticorelin, Cortrosyn, Cosyntropin, CRF (ovine), oCRH, ovine CRH, Tetracosactide
Source Corticorelin ovine triflutate at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Corticorelin ovine trifluoroacetate (cosyntropin) is a synthetic 24‑amino‑acid peptide identical to the N‑terminal segment of ovine ACTH, used primarily for the diagnostic ACTH stimulation test.
Mechanism of Action
Agonist of melanocortin 2 receptor (MC2R) on adrenal cortical cells, stimulating cortisol synthesis and release.
Routes of Administration
Goals & Uses
- ACTH stimulation testDiagnosticHigh
- Assessment of adrenal insufficiencyDiagnosticHigh
- Differential diagnosis of Cushing's syndromeDiagnosticHigh
- Inferior petrosal sinus sampling (IPSS) adjunctDiagnosticHigh
- Evaluation of hypothalamic-pituitary-adrenal (HPA) axis functionDiagnosticModerate
Contraindications
- Concurrent heparin administrationDrug InteractionModerate
- Hypersensitivity to cosyntropin or any component of the formulationAllergyHigh
- Hypersensitivity to corticorelin or ovine proteinsAllergy/ImmunologyHigh
Adverse Effects
- AnaphylaxisImmunologicRareSevere life-threatening allergic reaction
- Facial flushingCardiovascular/DermatologicCommon
- Injection site reactionsLocalUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- HypotensionCardiovascularUncommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- DyspneaRespiratoryRareShortness of breath
Drug Interactions
- HeparinModerate
- KetoconazoleModerate
- Exogenous glucocorticoidsModerate
- Glucocorticoids (exogenous)Moderate
- MetyraponeLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- ElderlyAgeRelative
- Patients with known allergy to ovine proteinsAllergyAbsolute
Regulatory Status
- European UnionApprovedApproved: ACTH stimulation testEMA‑approved under similar indications.
- United StatesApprovedApproved: ACTH stimulation testFDA‑approved as Cosyntropin for diagnostic use.
- United KingdomApprovedApproved: ACTH stimulation testMHRA‑approved.
Approved for diagnostic evaluation of adrenal insufficiency and for assessment of cortisol reserve.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Corticorelin ovine triflutate?
Corticorelin ovine trifluoroacetate (cosyntropin) is a synthetic 24‑amino‑acid peptide identical to the N‑terminal segment of ovine ACTH, used primarily for the diagnostic ACTH stimulation test.
What is Corticorelin ovine triflutate used for?
Corticorelin ovine triflutate is educationally associated with: ACTH stimulation test, Assessment of adrenal insufficiency, Differential diagnosis of Cushing's syndrome, Inferior petrosal sinus sampling (IPSS) adjunct, Evaluation of hypothalamic-pituitary-adrenal (HPA) axis function. Educational only — not medical advice.
How is Corticorelin ovine triflutate administered?
Recorded routes of administration: Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Corticorelin ovine triflutate?
Reported adverse effects include: Anaphylaxis, Facial flushing, Injection site reactions, Headache, Hypotension, Flushing, Tachycardia, Nausea, Dyspnea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Corticorelin ovine triflutate?
Recorded contraindications: Concurrent heparin administration, Hypersensitivity to cosyntropin or any component of the formulation, Hypersensitivity to corticorelin or ovine proteins. Consult a qualified clinician before use.