Demoxytocin
Also known as: 1-deamino-oxytocin, Deamino-oxytocin, Demoxytocin, Desaminooxytocin, Moxytocin, Sandopart
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Summary
Synthetic oxytocin analog used as a uterotonic to induce labor and control postpartum hemorrhage.
Mechanism of Action
Selective agonist of the oxytocin receptor, stimulating uterine smooth‑muscle contraction
Routes of Administration
Goals & Uses
- Induction of laborObstetricsModerate
- Augmentation of laborObstetricsModerate
- Promotion of lactation / milk ejectionLactationModerate
- Third stage of labor managementObstetricsLow
- Labor inductionObstetricsModerate
- Postpartum hemorrhage prophylaxisObstetricsModerate
- Control of postpartum hemorrhageObstetricsModerate
Contraindications
- Cephalopelvic disproportionObstetricHigh
- Placenta praeviaObstetricHigh
- Hypersensitivity to demoxytocin or oxytocinAllergyHigh
- Fetal malpresentation requiring cesareanObstetricHigh
- Placenta previaObstetricHigh
- Hypertonic uterine contractionsObstetricHigh
- Vasa praeviaObstetricHigh
- Fetal distressObstetricHigh
Adverse Effects
- Allergic reactionsImmunologicalRare
- Uterine hyperstimulationUterineCommon
- HypotensionCardiovascularUncommonLow blood pressure
- Water intoxicationRenalRare
- Nausea and vomitingGastrointestinalCommon
- Water retention / hyponatremiaMetabolicUncommon
- Fetal bradycardiaNeonatalUncommon
Drug Interactions
- Prostaglandin analogsModerate
- General anesthetics (e.g., halothane)Moderate
- Prostaglandins (e.g., dinoprostone, misoprostol)High
- OxytocinModerate
- Vasoconstrictors (sympathomimetics)Moderate
- Ergot alkaloids (e.g., ergometrine)Moderate
Population Constraints
- Grand multiparous womenObstetricRelative
- Women with cardiovascular diseaseCardiovascularRelative
- Women with prior uterine surgery or cesarean sectionObstetric HistoryRelative
- Elderly patientsAgeRelative
- Pregnant women (non-obstetric use)PregnancyAbsolute
- Pregnant women (≥37 weeks gestation)ObstetricAbsolute
- NeonatesPediatricRelative
Regulatory Status
- European UnionApprovedApproved: Labor induction, Postpartum hemorrhageApproved in several EU member states.
- United StatesUnapprovedNot approved by FDA.
- United KingdomApprovedApproved: Labor inductionApproved for obstetric use.
Approved for obstetric use in several European and Asian countries; not approved by the FDA in the United States.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Demoxytocin?
Synthetic oxytocin analog used as a uterotonic to induce labor and control postpartum hemorrhage.
What is Demoxytocin used for?
Demoxytocin is educationally associated with: Induction of labor, Augmentation of labor, Promotion of lactation / milk ejection, Third stage of labor management, Labor induction, Postpartum hemorrhage prophylaxis, Control of postpartum hemorrhage. Educational only — not medical advice.
How is Demoxytocin administered?
Recorded routes of administration: Buccal, Intramuscular, Intravenous, Nasal, Subcutaneous, Sublingual.
What are the potential side effects of Demoxytocin?
Reported adverse effects include: Allergic reactions, Uterine hyperstimulation, Hypotension, Water intoxication, Nausea and vomiting, Water retention / hyponatremia, Fetal bradycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Demoxytocin?
Recorded contraindications: Cephalopelvic disproportion, Placenta praevia, Hypersensitivity to demoxytocin or oxytocin, Fetal malpresentation requiring cesarean, Placenta previa, Hypertonic uterine contractions, Vasa praevia, Fetal distress. Consult a qualified clinician before use.