Recombinant Coagulation and Plasma Proteins
2 compounds in this family, each with its recorded mechanism, routes of administration, safety notes and references to published literature.
- OcriplasminOcriplasmin (Jetrea) is a recombinant truncated human plasmin administered by intravitreal injection to treat symptomatic vitreomacular adhesion (sVMA) and vitreomacular traction (VMT). By enzymatically cleaving proteins that hold the vitreous to the macula, it aims to induce posterior vitreous detachment, resolve adhesion, close small macular holes, and reduce the need for surgical vitrectomy.
- Recombinant human plasma gelsolinRecombinant human plasma gelsolin (rhu‑pGSN) is an 83 kDa actin‑binding protein produced by recombinant technology and administered intravenously. It is being explored as an investigational immunomodulatory therapy for conditions marked by excessive inflammation, such as severe COVID‑19 pneumonia, community‑acquired pneumonia, and decompression‑related neuroinflammation.