gamma-Glutamylcysteine
Also known as: gamma-L-glutamyl-L-cysteine, GGC, L-gamma-glutamyl-L-cysteine, γ-GC, γ-glutamylcysteine, γ‑GC, γ‑Glutamylcysteine
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Summary
γ‑Glutamylcysteine is a naturally occurring dipeptide that is the rate‑limiting substrate for glutathione synthetase, boosting intracellular glutathione levels and supporting antioxidant capacity.
Mechanism of Action
serves as the immediate precursor for glutathione synthesis; provides cysteine for antioxidant defense
Routes of Administration
Goals & Uses
- increase glutathioneAntioxidant SupportModerate
- Oxidative stress reductionAntioxidantModerate
- Glutathione replenishmentAntioxidant / CytoprotectionModerate
- NeuroprotectionNeurologyLow
- HepatoprotectionCytoprotectionLow
- Skin anti-aging / brighteningCosmetic / DermatologyLow
Contraindications
- Known hypersensitivity to γ-GC or structurally related compoundsAllergyHigh
- Cystinuria or cystine stone diseaseMetabolic DisorderModerate
- cystinuriaMetabolic DisorderModerate
Adverse Effects
- Injection site irritationLocal ReactionUncommon
- Gastrointestinal upsetGastrointestinalCommon
- Theoretical pro-oxidant effects at supraphysiologic dosesOxidativeUnknown
- Sulfur-related gastrointestinal discomfortGastrointestinalUncommon
Drug Interactions
- Cisplatin / alkylating chemotherapeuticsModerate
- Buthionine sulfoximine (BSO)Moderate
- N‑acetylcysteineLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Renal impairmentOrgan ImpairmentRelative
- Pediatric populationAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionUnapprovedmarketed as food supplement under novel food regulations
- United StatesUnapprovedavailable as dietary supplement, not an FDA‑approved drug
- United KingdomUnapprovedNot approved by MHRA as a medicinal product.
Not approved as a drug by FDA, EMA, or MHRA. Available as a research chemical and appears in some dietary supplement formulations. No IND or NDA on record as a standalone therapeutic.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is gamma-Glutamylcysteine?
γ‑Glutamylcysteine is a naturally occurring dipeptide that is the rate‑limiting substrate for glutathione synthetase, boosting intracellular glutathione levels and supporting antioxidant capacity.
What is gamma-Glutamylcysteine used for?
gamma-Glutamylcysteine is educationally associated with: increase glutathione, Oxidative stress reduction, Glutathione replenishment, Neuroprotection, Hepatoprotection, Skin anti-aging / brightening. Educational only — not medical advice.
How is gamma-Glutamylcysteine administered?
Recorded routes of administration: Intravenous, Oral, Topical.
What are the potential side effects of gamma-Glutamylcysteine?
Reported adverse effects include: Injection site irritation, Gastrointestinal upset, Theoretical pro-oxidant effects at supraphysiologic doses, Sulfur-related gastrointestinal discomfort. This list is not exhaustive — consult a qualified clinician.
Who should avoid gamma-Glutamylcysteine?
Recorded contraindications: Known hypersensitivity to γ-GC or structurally related compounds, Cystinuria or cystine stone disease, cystinuria. Consult a qualified clinician before use.