Hexapeptide-2
Also known as: Ac-Lys-DPhe-Arg-Trp-Dap-NH2, Acetyl hexapeptide-2, MC1R antagonist peptide, Melanostatine-5
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Summary
Hexapeptide-2 is a synthetic hexapeptide employed in topical anti‑aging products to improve skin firmness and diminish wrinkle depth.
Mechanism of Action
hypothesized modulation of neurotransmitter release to reduce facial muscle contraction
Routes of Administration
Goals & Uses
- Dark spot treatmentCosmetic / DermatologyLow
- Reduction of hyperpigmentationDermatology / CosmeticLow
- Skin brightening and evening of skin toneCosmeticLow
- Reduction of UV-induced pigmentationPhotoprotection / CosmeticLow
Contraindications
- Application to broken or inflamed skinSkin IntegrityLow
- Known hypersensitivity to peptide componentsAllergyModerate
Adverse Effects
- Local skin irritationDermatologicalUncommon
- Contact dermatitisDermatologicalRare
- Over-depigmentationDermatologicalRare
Drug Interactions
- Other depigmenting agents (e.g., hydroquinone, kojic acid)Low
Population Constraints
- Pregnant or breastfeeding individualsReproductive SafetyRelative
- ChildrenPediatricRelative
Regulatory Status
- European UnionUnapprovedPermitted for cosmetic use under EU Cosmetics Regulation (EC) No 1223/2009 as a cosmetic ingredient.
- United StatesUnapprovedUsed as a cosmetic ingredient only; not FDA-approved as a drug. Regulated under cosmetic category.
- United KingdomUnapprovedConsidered a cosmetic ingredient under UK cosmetics regulations; no drug approval.
Regulated as a cosmetic ingredient in most jurisdictions; not FDA-approved as a drug. Used under cosmetic regulation (e.g., EU Cosmetics Regulation). No clinical drug approval exists.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Hexapeptide-2?
Hexapeptide-2 is a synthetic hexapeptide employed in topical anti‑aging products to improve skin firmness and diminish wrinkle depth.
What is Hexapeptide-2 used for?
Hexapeptide-2 is educationally associated with: Dark spot treatment, Reduction of hyperpigmentation, Skin brightening and evening of skin tone, Reduction of UV-induced pigmentation. Educational only — not medical advice.
How is Hexapeptide-2 administered?
Recorded routes of administration: Topical.
What are the potential side effects of Hexapeptide-2?
Reported adverse effects include: Local skin irritation, Contact dermatitis, Over-depigmentation. This list is not exhaustive — consult a qualified clinician.
Who should avoid Hexapeptide-2?
Recorded contraindications: Application to broken or inflamed skin, Known hypersensitivity to peptide components. Consult a qualified clinician before use.