Insulin aspart

Insulin AnalogRx: PrescriptionCompound: Approved

Also known as: Asp(B28) insulin, Fiasp, IAsp, Insulin aspart, NovoLog, NovoRapid

Educational Only — Not medical advice. Consult a qualified clinician before using any peptide.

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Summary

Rapid-acting insulin analog used to control blood glucose in type 1 and type 2 diabetes mellitus.

Mechanism of Action

Activates the insulin receptor tyrosine kinase, enhancing glucose uptake and metabolism

Routes of Administration

Continuous Subcutaneous Infusion (insulin Pump)IntravenousSubcutaneous

Goals & Uses

  • Diabetic ketoacidosis treatment (IV)Emergency Glycemic ManagementModerate
  • Type 2 diabetes mellitus managementGlycemic ManagementHigh
  • Glycemic controlDiabetesHigh
  • Type 1 diabetes mellitus managementGlycemic ManagementHigh
  • Gestational diabetes / diabetes in pregnancyGlycemic ManagementHigh
  • Postprandial glucose controlGlycemic ManagementHigh

Contraindications

  • Known hypersensitivity to insulin aspart or excipientsAllergicHigh
  • Hypersensitivity to insulin aspart or excipientsImmunologicHigh
  • Hypoglycemia (active episode)MetabolicHigh
  • HypoglycemiaMetabolicHigh

Adverse Effects

  • HypokalemiaElectrolyteUncommon
  • HypoglycemiaMetabolicCommonAbnormally low blood glucose
  • Peripheral edemaFluid BalanceUncommonSwelling of the arms or legs
  • Injection site reactionsLocalCommon
  • Allergic reactions / anaphylaxisImmunologicRare
  • Weight gainMetabolicCommonIncrease in body weight
  • LipodystrophyDermatologicUncommon

Drug Interactions

  • Thiazolidinediones (e.g., pioglitazone)Moderate
  • Salicylates (high-dose aspirin)Low
  • Beta-blockersModerate
  • AlcoholModerate
  • CorticosteroidsModerate
  • MAO inhibitorsModerate
  • ACE inhibitorsLow

Population Constraints

  • Pediatrics (<6 years)AgeRelative
  • PregnancyReproductive SafetyRelative
  • Hepatic impairmentOrgan FunctionRelative
  • Renal impairmentOrgan ImpairmentRelative
  • Elderly patientsAgeRelative
  • Pediatric patients (<2 years)AgeRelative

Regulatory Status

  • European UnionApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitusMarketed as NovoRapid
  • United StatesApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitusMarketed as NovoLog
  • United KingdomApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitusAvailable under NHS formularies

Approved in US (FDA), EU (EMA), and many other jurisdictions; indicated for mealtime insulin therapy.

Evidence & Sources

No sources recorded yet.

Frequently Asked Questions

What is Insulin aspart?

Rapid-acting insulin analog used to control blood glucose in type 1 and type 2 diabetes mellitus.

What is Insulin aspart used for?

Insulin aspart is educationally associated with: Diabetic ketoacidosis treatment (IV), Type 2 diabetes mellitus management, Glycemic control, Type 1 diabetes mellitus management, Gestational diabetes / diabetes in pregnancy, Postprandial glucose control. Educational only — not medical advice.

How is Insulin aspart administered?

Recorded routes of administration: Continuous Subcutaneous Infusion (insulin Pump), Intravenous, Subcutaneous.

What are the potential side effects of Insulin aspart?

Reported adverse effects include: Hypokalemia, Hypoglycemia, Peripheral edema, Injection site reactions, Allergic reactions / anaphylaxis, Weight gain, Lipodystrophy. This list is not exhaustive — consult a qualified clinician.

Who should avoid Insulin aspart?

Recorded contraindications: Known hypersensitivity to insulin aspart or excipients, Hypersensitivity to insulin aspart or excipients, Hypoglycemia (active episode), Hypoglycemia. Consult a qualified clinician before use.

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