NAD+
Also known as: Coenzyme I, NAD, Nicotinamide adenine dinucleotide, oxidized nicotinamide adenine dinucleotide, β-NAD+
Source NAD+ at Peptiology
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Summary
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme and signaling molecule central to cellular energy metabolism, redox homeostasis, and enzyme regulation. Not a peptide in strict biochemical definition, but functionally peptide-associated in metabolic and longevity research contexts.
Mechanism of Action
substrate for NAD+-consuming enzymes (sirtuins, PARPs, CD38); electron carrier in redox reactions; regulates cellular energy metabolism and signaling
Routes of Administration
Goals & Uses
- longevity/healthy agingAnti AgingLow
- metabolic supportGeneral WellnessModerate
- energy enhancementPerformanceLow
Contraindications
- malignancyOncologyModerate
Adverse Effects
- HeadacheNeurologicUncommonPain in the head or upper neck
- HypotensionCardiovascularRareLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
Drug Interactions
- niacin/niacinamideLow
- sirtuin-activating compounds (STACs)Low
Population Constraints
- PregnancyReproductive SafetyRelative
- PediatricAgeRelative
- LactationReproductiveRelative
Regulatory Status
- European UnionApprovedApproved: food supplementRegulated as food/food supplement, not medicinal product
- United StatesApprovedApproved: dietary supplement ingredientNot approved as drug; GRAS status for precursors debated
- United KingdomApprovedApproved: food supplementMHRA does not regulate as medicine
Marketed as dietary supplement; FDA does not recognize NAD+ as a drug. Precursor forms (NMN, NR) more commonly supplemented due to poor oral bioavailability of NAD+ itself.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme and signaling molecule central to cellular energy metabolism, redox homeostasis, and enzyme regulation. Not a peptide in strict biochemical definition, but functionally peptide-associated in metabolic and longevity research contexts.
What is NAD+ used for?
NAD+ is educationally associated with: longevity/healthy aging, metabolic support, energy enhancement. Educational only — not medical advice.
How is NAD+ administered?
Recorded routes of administration: Intravenous, Oral, Subcutaneous.
What are the potential side effects of NAD+?
Reported adverse effects include: Headache, Hypotension, Flushing, Nausea. This list is not exhaustive — consult a qualified clinician.
Who should avoid NAD+?
Recorded contraindications: malignancy. Consult a qualified clinician before use.