Nepadutant
Also known as: MEN 11420, MEN-11420, N-9, Nepadutant
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Summary
Nepadutant is a synthetic peptide antagonist of the NK2 tachykinin receptor that has been evaluated in clinical trials for asthma, irritable bowel syndrome, and chronic pain. It has not received regulatory approval.
Mechanism of Action
Competitive antagonist at neurokinin‑2 (NK2) receptors, blocking tachykinin‑mediated smooth‑muscle contraction and neurogenic inflammation
Routes of Administration
Goals & Uses
- Visceral PainPain / GastroenterologyModerate
- Asthma / BronchoconstrictionRespiratoryLow
- Chronic PainPainLow
- Irritable Bowel SyndromeGastrointestinalModerate
- Irritable Bowel Syndrome (IBS)GastrointestinalModerate
- Infantile ColicGastrointestinal / PediatricLow
- AsthmaRespiratoryModerate
Contraindications
- Hypersensitivity to nepadutant or excipientsAllergyHigh
- Known hypersensitivity to nepadutantAllergyHigh
Adverse Effects
- Injection site reactionsLocalUncommon
- HeadacheNeurologicUncommonPain in the head or upper neck
- Gastrointestinal discomfortGastrointestinalUncommon
- Injection site erythemaLocalCommonRedness at the injection site
Drug Interactions
- Beta‑agonistsLow
- CYP3A4 substrates / inhibitorsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric populations (neonates/infants)AgeRelative
- Severe hepatic impairmentOrgan ImpairmentRelative
Regulatory Status
- European UnionInvestigationalClinical development discontinued.
- United StatesInvestigationalPhase II completed, no NDA filed.
- United KingdomInvestigationalNo MHRA approval; remains investigational
No approved indication; development halted after Phase II trials due to limited efficacy.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Nepadutant?
Nepadutant is a synthetic peptide antagonist of the NK2 tachykinin receptor that has been evaluated in clinical trials for asthma, irritable bowel syndrome, and chronic pain. It has not received regulatory approval.
What is Nepadutant used for?
Nepadutant is educationally associated with: Visceral Pain, Asthma / Bronchoconstriction, Chronic Pain, Irritable Bowel Syndrome, Irritable Bowel Syndrome (IBS), Infantile Colic, Asthma. Educational only — not medical advice.
How is Nepadutant administered?
Recorded routes of administration: Intravenous, Oral, Subcutaneous.
What are the potential side effects of Nepadutant?
Reported adverse effects include: Injection site reactions, Headache, Gastrointestinal discomfort, Injection site erythema. This list is not exhaustive — consult a qualified clinician.
Who should avoid Nepadutant?
Recorded contraindications: Hypersensitivity to nepadutant or excipients, Known hypersensitivity to nepadutant. Consult a qualified clinician before use.