P-113D
Also known as: D‑P‑113, Histatin-5 D-analogue, P‑113D, P113D, PAC-113
Source P-113D at Peptiology
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Summary
P-113D is a D‑amino‑acid analog of the histatin‑derived peptide P‑113, investigated for antifungal and antibacterial activity, particularly against oral Candida and drug‑resistant bacteria.
Mechanism of Action
Membrane disruption and intracellular targeting of microbes; D‑amino acid substitution enhances protease resistance and broadens antimicrobial spectrum.
Routes of Administration
Goals & Uses
- Broad-spectrum antifungal activityAntifungalModerate
- Biofilm disruptionAntimicrobialLow
- Broad‑spectrum antibacterial therapyAntibacterialLow
- Periodontal infection controlAntibacterialLow
- Oral candidiasis treatmentAntifungalModerate
Contraindications
- Known hypersensitivity to histatin peptidesAllergyHigh
Adverse Effects
- Taste disturbanceSensoryUncommonAltered sense of taste
- Local irritationDermatologicCommon
- Hypersensitivity reactionImmunologicRare
- Local oral irritationLocal ReactionUncommon
Drug Interactions
- Zinc-containing productsLow
Population Constraints
- Pediatric patientsAgeRelative
- Severely immunocompromised patients with systemic candidiasisDisease SeverityRelative
- Pregnant or lactating womenReproductiveRelative
Regulatory Status
- European UnionUnapprovedResearch use only.
- United StatesUnapprovedInvestigational peptide; no FDA approval.
- United KingdomUnknownNo MHRA approval identified.
No regulatory approval in any jurisdiction. Investigated in early-phase clinical trials for oral candidiasis in HIV-positive patients. Development has remained at investigational/research stage.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is P-113D?
P-113D is a D‑amino‑acid analog of the histatin‑derived peptide P‑113, investigated for antifungal and antibacterial activity, particularly against oral Candida and drug‑resistant bacteria.
What is P-113D used for?
P-113D is educationally associated with: Broad-spectrum antifungal activity, Biofilm disruption, Broad‑spectrum antibacterial therapy, Periodontal infection control, Oral candidiasis treatment. Educational only — not medical advice.
How is P-113D administered?
Recorded routes of administration: Intravenous, Oral, Oral (topical/rinse), Topical.
What are the potential side effects of P-113D?
Reported adverse effects include: Taste disturbance, Local irritation, Hypersensitivity reaction, Local oral irritation. This list is not exhaustive — consult a qualified clinician.
Who should avoid P-113D?
Recorded contraindications: Known hypersensitivity to histatin peptides. Consult a qualified clinician before use.