PNC-27
Also known as: HDM-2 binding peptide, p53(12-26), PNC27, Pronco-27
Source PNC-27 at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Synthetic peptide derived from p53 residues 12-26 designed to target HDM-2 overexpressed on cancer cell surfaces, inducing selective cancer cell death without harming normal cells
Mechanism of Action
Binds to HDM-2 (human double minute 2) on cancer cell membranes, forming pores and inducing membranolysis; releases p53 from HDM-2 inhibition, restoring p53-mediated apoptosis
Routes of Administration
Goals & Uses
- cancer treatmentOncologyModerate
- p53 restoration therapyTargeted TherapyModerate
Contraindications
No contraindications recorded yet.
Adverse Effects
- Injection site reactionsLocalUnknown
- off-target membranolysisSystemicRare
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- p53-mutant cancersTumor GeneticsRelative
- HDM-2-negative cancersTumor BiologyAbsolute
Regulatory Status
- European UnionUnapprovedNo EMA approval
- United StatesUnapprovedNo FDA approval; not listed in clinicaltrials.gov with active enrollment
Not approved for clinical use; preclinical studies ongoing; early-phase clinical trials reported in literature but not registered in major trial databases
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is PNC-27?
Synthetic peptide derived from p53 residues 12-26 designed to target HDM-2 overexpressed on cancer cell surfaces, inducing selective cancer cell death without harming normal cells
What is PNC-27 used for?
PNC-27 is educationally associated with: cancer treatment, p53 restoration therapy. Educational only — not medical advice.
How is PNC-27 administered?
Recorded routes of administration: Intraperitoneal, Intravenous.
What are the potential side effects of PNC-27?
Reported adverse effects include: Injection site reactions, off-target membranolysis. This list is not exhaustive — consult a qualified clinician.