Prezatide
Also known as: Copper Tripeptide-1, GHK, GHK-Cu, Iamin, Prezatide copper acetate
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Summary
Prezatide copper acetate (GHK-Cu) is a synthetic tripeptide-copper complex originally developed for wound healing and skin repair. It has been investigated in topical formulations for oral mucosal healing and wound repair. The compound occurs naturally in human plasma and has a broad range of biological activities including collagen stimulation, angiogenesis, and anti-inflammatory effects.
Mechanism of Action
Prezatide (GHK-Cu) is a copper-chelating tripeptide that binds copper(II) ions. It activates wound healing processes by stimulating collagen synthesis, promoting angiogenesis, activating antioxidant defenses, and modulating matrix metalloproteinase activity. It also has anti-inflammatory properties and promotes tissue remodeling.
Routes of Administration
Goals & Uses
- Hair growth promotionDermatology / TrichologyLow
- Oral mucosal wound healingOral MedicineModerate
- Collagen synthesis stimulationDermatology / Anti AgingModerate
- Wound healing accelerationRegenerative MedicineModerate
- Skin repair and anti-agingDermatologyModerate
- Anti-inflammatory effectsInflammationLow
Contraindications
- Active infection at application siteInfectiousModerate
- Hypersensitivity to copper or peptide componentsAllergyHigh
- Wilson's diseaseMetabolic DisorderHigh
Adverse Effects
- Local skin irritationDermatologicalUncommon
- Contact dermatitisDermatologicalRare
- Copper accumulation (theoretical)MetabolicRare
Drug Interactions
- PenicillamineModerate
- Zinc supplementsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Patients with copper metabolism disordersMetabolicAbsolute
Regulatory Status
- European UnionUnapprovedNot approved as a drug in the EU; used as a cosmetic ingredient under INCI name Copper Tripeptide-1.
- United StatesInvestigationalInvestigated by FDA as a topical drug for oral mucosal wound healing; not broadly approved as a pharmaceutical. Present in OTC cosmetics as Copper Tripeptide-1.
- United KingdomUnapprovedNo regulatory drug approval in the UK; available as a cosmetic ingredient.
Prezatide copper acetate was investigated as a topical wound healing agent. It received some regulatory attention in the US for oral mucosal injuries. It is present in some cosmetic and dermatological products under the INCI name Copper Tripeptide-1. Its regulatory status as a drug is limited; it is not broadly FDA-approved as a pharmaceutical drug for systemic use.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Prezatide?
Prezatide copper acetate (GHK-Cu) is a synthetic tripeptide-copper complex originally developed for wound healing and skin repair. It has been investigated in topical formulations for oral mucosal healing and wound repair. The compound occurs naturally in human plasma and has a broad range of biological activities including collagen stimulation, angiogenesis, and anti-inflammatory effects.
What is Prezatide used for?
Prezatide is educationally associated with: Hair growth promotion, Oral mucosal wound healing, Collagen synthesis stimulation, Wound healing acceleration, Skin repair and anti-aging, Anti-inflammatory effects. Educational only — not medical advice.
How is Prezatide administered?
Recorded routes of administration: Subcutaneous, Topical.
What are the potential side effects of Prezatide?
Reported adverse effects include: Local skin irritation, Contact dermatitis, Copper accumulation (theoretical). This list is not exhaustive — consult a qualified clinician.
Who should avoid Prezatide?
Recorded contraindications: Active infection at application site, Hypersensitivity to copper or peptide components, Wilson's disease. Consult a qualified clinician before use.