Sermorelin
Also known as: Geref, Geref Diagnostic, GHRH(1-29)-NH2, GRF 1-29, Sermorelin, Sermorelin acetate
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Summary
Sermorelin is a synthetic 29‑amino‑acid analogue of endogenous GHRH used to stimulate growth hormone secretion in children with GH deficiency and for diagnostic GH‑reserve testing.
Mechanism of Action
Binds to the GHRH receptor on pituitary somatotrophs, stimulating synthesis and release of endogenous growth hormone.
Routes of Administration
Goals & Uses
- Muscle mass and recoveryPerformance / Body CompositionLow
- Reduction of adiposityMetabolicLow
- Adult GH deficiency / body composition improvementOff Label / Anti AgingModerate
- Treatment of pediatric idiopathic GH deficiencyTherapeuticHigh
- Increase endogenous GH secretionTherapeuticModerate
- Improved sleep qualityOff Label / WellnessLow
- Diagnosis of growth hormone deficiencyDiagnosticHigh
- Diagnostic assessment of GH reserveDiagnosticHigh
Contraindications
- Hypothyroidism (untreated)EndocrineModerate
- ObesityMetabolicLow
- Active malignancyOncologyHighUse caution or avoid depending on agent and context
- Active intracranial neoplasmOncologicHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Known hypersensitivity to sermorelin or componentsAllergy / ImmunologicHigh
Adverse Effects
- HyperglycemiaMetabolicUncommonAbnormally high blood glucose
- Hypersensitivity / anaphylaxisImmunologicalRare
- Injection site reactionsLocalCommon
- Injection site painLocalCommonPain at the injection site
- HeadacheNeurologicUncommonPain in the head or upper neck
- FlushingVascularCommonWarmth and redness of the skin
- Elevated IGF-1 / GH excessEndocrine / MetabolicUncommon
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
Drug Interactions
- GlucocorticoidsModerate
- Thyroid hormonesLow
- Somatostatin analogs (e.g., octreotide)High
- Exogenous GH (somatropin)Moderate
- Insulin / antidiabetic agentsModerate
Population Constraints
- Patients with prior or active malignancyOncologyRelative
- Children (<18 y)AgeRelative
- Pediatric patients under 2 yearsAgeRelative
- Patients with diabetes mellitusMetabolicRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
- Elderly (>65 y)AgeRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization in European Union.
- United StatesApprovedApproved: pediatric growth hormone deficiencyBrand Geref withdrawn from market in 2008 but remains FDA‑approved.
- United KingdomUnapprovedNot licensed for clinical use.
FDA‑approved (1996) for pediatric GH deficiency under the brand Geref; later discontinued in the US market but remains available for research and off‑label use.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Sermorelin?
Sermorelin is a synthetic 29‑amino‑acid analogue of endogenous GHRH used to stimulate growth hormone secretion in children with GH deficiency and for diagnostic GH‑reserve testing.
What is Sermorelin used for?
Sermorelin is educationally associated with: Muscle mass and recovery, Reduction of adiposity, Adult GH deficiency / body composition improvement, Treatment of pediatric idiopathic GH deficiency, Increase endogenous GH secretion, Improved sleep quality, Diagnosis of growth hormone deficiency, Diagnostic assessment of GH reserve. Educational only — not medical advice.
How is Sermorelin administered?
Recorded routes of administration: Intravenous, Subcutaneous.
What are the potential side effects of Sermorelin?
Reported adverse effects include: Hyperglycemia, Hypersensitivity / anaphylaxis, Injection site reactions, Injection site pain, Headache, Flushing, Elevated IGF-1 / GH excess, Nausea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Sermorelin?
Recorded contraindications: Hypothyroidism (untreated), Obesity, Active malignancy, Active intracranial neoplasm, Pregnancy, Known hypersensitivity to sermorelin or components. Consult a qualified clinician before use.