Taltirelin
Also known as: Ceredist, L-TRH analog, N-[(4S)-hexahydro-2,6-dioxo-4-pyrimidinylcarbonyl]-L-histidyl-L-prolinamide, TA-0910, TA‑0910, Taltirelin
Source Taltirelin at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Taltirelin (TA‑0910) is a synthetic, long‑acting analog of the tripeptide hormone TRH. It is used clinically in Japan to enhance central nervous system activity, improving cognition and motor function in certain neurodegenerative conditions.
Mechanism of Action
Agonist at TRH receptors (TRH-R1/2) leading to increased release of TSH, modulation of cholinergic and dopaminergic neurotransmission in the CNS
Routes of Administration
Goals & Uses
- NeuroprotectionNeurologyLow
- Cognitive impairmentNeurologyModerate
- Spinocerebellar degeneration treatmentNeurologicalModerate
- Amyotrophic lateral sclerosis (ALS) treatmentNeurologicalLow
- Motor dysfunction in Parkinsonian syndromesNeurologyModerate
- DepressionPsychiatryLow
- Cerebellar ataxia symptom reliefNeurologicalModerate
Contraindications
- HyperthyroidismEndocrineHigh
- Hypersensitivity to taltirelin or TRH analoguesAllergyHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Pituitary adenomaOncologyModerate
- Pituitary apoplexy or pituitary tumorsEndocrineHigh
Adverse Effects
- Urinary urgencyGenitourinaryUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- HypotensionCardiovascularUncommonLow blood pressure
- Increased blood pressureCardiovascularUncommon
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- VomitingGastrointestinalCommonForceful expulsion of stomach contents
- Elevation of thyroid-stimulating hormone (TSH)EndocrineCommon
- Hot flush / warmth sensationAutonomicCommon
Drug Interactions
- Antihypertensive agentsModerate
- LevothyroxineModerate
- CNS depressants (e.g., benzodiazepines)Low
- Thyroid hormone medications (levothyroxine)Moderate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatrics (<12 y)AgeRelative
- Elderly (>75 y)AgeRelative
- Patients with cardiac diseaseCardiovascularRelative
- Elderly patientsAgeRelative
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionUnapprovedNot authorized for marketing.
- JPApprovedApproved: cognitive impairment associated with neurodegenerative diseaseMarketed as a prescription drug in Japan.
- United StatesInvestigationalUnder IND for clinical trials.
- United KingdomUnapprovedNot approved by the MHRA.
Approved in Japan (marketed as Ceredist) for spinocerebellar degeneration. Not approved by the FDA or EMA. Classified as a prescription drug in Japan.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Taltirelin?
Taltirelin (TA‑0910) is a synthetic, long‑acting analog of the tripeptide hormone TRH. It is used clinically in Japan to enhance central nervous system activity, improving cognition and motor function in certain neurodegenerative conditions.
What is Taltirelin used for?
Taltirelin is educationally associated with: Neuroprotection, Cognitive impairment, Spinocerebellar degeneration treatment, Amyotrophic lateral sclerosis (ALS) treatment, Motor dysfunction in Parkinsonian syndromes, Depression, Cerebellar ataxia symptom relief. Educational only — not medical advice.
How is Taltirelin administered?
Recorded routes of administration: Intramuscular, Intravenous, Oral, Subcutaneous.
What are the potential side effects of Taltirelin?
Reported adverse effects include: Urinary urgency, Headache, Hypotension, Increased blood pressure, Nausea, Vomiting, Elevation of thyroid-stimulating hormone (TSH), Hot flush / warmth sensation. This list is not exhaustive — consult a qualified clinician.
Who should avoid Taltirelin?
Recorded contraindications: Hyperthyroidism, Hypersensitivity to taltirelin or TRH analogues, Pregnancy, Pituitary adenoma, Pituitary apoplexy or pituitary tumors. Consult a qualified clinician before use.