Thiostrepton
Also known as: Bryamycin, Thiactin, Thiostrepton A, TSR
Source Thiostrepton at Peptiology
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Summary
Thiostrepton is a macrocyclic thiopeptide produced by Streptomyces species, active against Gram‑positive bacteria. It is used primarily as a research tool and has not been approved for clinical use.
Mechanism of Action
Binds to the 23S rRNA of the bacterial ribosome, blocking elongation factor G and inhibiting protein synthesis
Routes of Administration
Goals & Uses
- Anti‑cancer researchOncologyModerate
- Anti-protozoal activity (malaria)Antiparasitic / ResearchLow
- Antibacterial activityInfectious DiseaseHigh
- Treatment of bacterial skin and ear infections (veterinary)Antimicrobial / VeterinaryHigh
- Anticancer activity via FOXM1 inhibitionOncology / ResearchLow
Contraindications
- Application to perforated tympanic membraneAnatomicalModerate
- Known hypersensitivity to thiostrepton or thiopeptide antibioticsAllergyHigh
Adverse Effects
- Local skin irritationDermatologicalUncommon
- Hypersensitivity reactionImmunologicRare
Drug Interactions
- Other aminoglycoside or ototoxic agents (otic use)Moderate
Population Constraints
- Humans (systemic use)Species/RouteAbsolute
- Pregnant animalsReproductiveRelative
Regulatory Status
- European UnionUnapprovedNot authorized for clinical use
- United StatesUnapprovedInvestigational only, no FDA approval
- United KingdomUnapprovedNo marketing authorization
Not approved for human therapy; limited to in‑vitro and animal research. No marketed formulation.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Thiostrepton?
Thiostrepton is a macrocyclic thiopeptide produced by Streptomyces species, active against Gram‑positive bacteria. It is used primarily as a research tool and has not been approved for clinical use.
What is Thiostrepton used for?
Thiostrepton is educationally associated with: Anti‑cancer research, Anti-protozoal activity (malaria), Antibacterial activity, Treatment of bacterial skin and ear infections (veterinary), Anticancer activity via FOXM1 inhibition. Educational only — not medical advice.
How is Thiostrepton administered?
Recorded routes of administration: Intravenous, Subcutaneous, Topical.
What are the potential side effects of Thiostrepton?
Reported adverse effects include: Local skin irritation, Hypersensitivity reaction. This list is not exhaustive — consult a qualified clinician.
Who should avoid Thiostrepton?
Recorded contraindications: Application to perforated tympanic membrane, Known hypersensitivity to thiostrepton or thiopeptide antibiotics. Consult a qualified clinician before use.