Tyrothricin
Also known as: Gramicidin/Tyrocidine mixture, Lemocin, Throatin, Tyrocidine/Gramicidin mixture, Tyrosur, Tyrothricin, Tyrothricin ointment
Source Tyrothricin at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Tyrothricin is a mixture of cyclic peptide antibiotics used topically to treat superficial bacterial skin infections.
Mechanism of Action
Forms ion channels in bacterial membranes, disrupting ion gradients and leading to cell death
Routes of Administration
Goals & Uses
- Treatment of sore throat and oral infectionsAntimicrobial / Local ENTModerate
- Topical skin infection treatmentDermatology / AntimicrobialModerate
- Oral cavity antisepsisDental / AntimicrobialLow
- treat superficial skin infectionsAntibacterialModerate
Contraindications
- Known hypersensitivity to tyrothricin or its componentsAllergyHigh
- Application to large open wounds or deep woundsWound TypeModerate
- Systemic administrationRoute Of AdministrationHigh
- hypersensitivity to tyrothricin or componentsAllergyHigh
Adverse Effects
- Local skin irritationDermatologicalCommon
- Contact dermatitisDermatologicalUncommon
- Local irritation or burning sensationLocal ReactionUncommon
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- HemolysisHematologicRare
- Allergic contact dermatitisImmunologicalRare
Drug Interactions
- Other topical antibioticsLow
- systemic antibioticsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Infants <2 monthsAgeRelative
- Patients with known hemolytic disordersHematologicalRelative
- Infants and neonatesPediatricRelative
Regulatory Status
- European UnionApprovedApproved: topical treatment of skin infectionsavailable as prescription ointment
- United StatesUnapprovednot FDA‑approved as a drug product
- United KingdomApprovedApproved: Topical/oromucosal antibacterial useAvailable in OTC throat lozenge formulations in the UK.
Approved in several European countries as an over-the-counter topical antiseptic and throat lozenge ingredient. Not systemically administered due to hemolytic toxicity. Available in Germany and other EU countries as lozenges (e.g., Tyrosur, Lemocin). Not formally approved by the FDA for any indication in the United States.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Tyrothricin?
Tyrothricin is a mixture of cyclic peptide antibiotics used topically to treat superficial bacterial skin infections.
What is Tyrothricin used for?
Tyrothricin is educationally associated with: Treatment of sore throat and oral infections, Topical skin infection treatment, Oral cavity antisepsis, treat superficial skin infections. Educational only — not medical advice.
How is Tyrothricin administered?
Recorded routes of administration: Oromucosal, Topical.
What are the potential side effects of Tyrothricin?
Reported adverse effects include: Local skin irritation, Contact dermatitis, Local irritation or burning sensation, Nausea, Hemolysis, Allergic contact dermatitis. This list is not exhaustive — consult a qualified clinician.
Who should avoid Tyrothricin?
Recorded contraindications: Known hypersensitivity to tyrothricin or its components, Application to large open wounds or deep wounds, Systemic administration, hypersensitivity to tyrothricin or components. Consult a qualified clinician before use.