Amphomycin
Also known as: Amphomycin A, Aspartocin, Calcium amphomycin, Glumamycin, L-658,234
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Summary
Amphomycin is a naturally occurring cyclic lipopeptide produced by Streptomyces griseus that exhibits potent activity against Gram‑positive organisms by disrupting cell‑wall assembly. It has never received regulatory approval and is used only in pre‑clinical research.
Mechanism of Action
Binds to undecaprenyl phosphate (bactoprenol), blocking peptidoglycan precursor translocation and inhibiting cell‑wall synthesis in Gram‑positive bacteria
Routes of Administration
Goals & Uses
- Gram-positive bacterial infection treatmentAntimicrobialLow
- treat resistant Gram‑positive infectionsAntibacterialModerate
- Topical antibacterial applicationAntimicrobialLow
- Inhibition of peptidoglycan biosynthesis (research tool)Research/mechanistic ProbeModerate
Contraindications
- Renal impairmentOrgan DysfunctionModerate
- Known hypersensitivity to amphomycin or related lipopeptidesAllergyHigh
Adverse Effects
- Hypersensitivity reactionsImmunologicUnknown
- Injection site reactionsLocalCommon
- NephrotoxicityRenalRare
Drug Interactions
- Nephrotoxic agents (e.g., aminoglycosides, NSAIDs)High
Population Constraints
- Pediatric patientsAgeRelative
- Pregnant womenReproductiveRelative
- Patients with pre-existing renal diseaseOrgan DysfunctionRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization.
- United StatesUnapprovedInvestigational use only under IND.
- United KingdomUnapprovedNot licensed for clinical use.
No FDA, EMA, or MHRA approval; classified as an investigational new drug (IND) only for experimental use.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Amphomycin?
Amphomycin is a naturally occurring cyclic lipopeptide produced by Streptomyces griseus that exhibits potent activity against Gram‑positive organisms by disrupting cell‑wall assembly. It has never received regulatory approval and is used only in pre‑clinical research.
What is Amphomycin used for?
Amphomycin is educationally associated with: Gram-positive bacterial infection treatment, treat resistant Gram‑positive infections, Topical antibacterial application, Inhibition of peptidoglycan biosynthesis (research tool). Educational only — not medical advice.
How is Amphomycin administered?
Recorded routes of administration: Intravenous, Subcutaneous, Topical.
What are the potential side effects of Amphomycin?
Reported adverse effects include: Hypersensitivity reactions, Injection site reactions, Nephrotoxicity. This list is not exhaustive — consult a qualified clinician.
Who should avoid Amphomycin?
Recorded contraindications: Renal impairment, Known hypersensitivity to amphomycin or related lipopeptides. Consult a qualified clinician before use.