Daptomycin
Also known as: Cubicin, Cubicin RF, Daptomycin, Daptomycin for injection, LY146032
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Summary
Daptomycin is a cyclic lipopeptide antibiotic administered intravenously for treatment of serious Gram‑positive infections such as complicated skin and soft‑tissue infections, bacteremia, and right‑sided endocarditis, including MRSA.
Mechanism of Action
Binds bacterial cell membrane causing rapid depolarization and loss of membrane potential, leading to cell death
Routes of Administration
Goals & Uses
- MRSA osteomyelitisInfectious DiseaseModerate
- Complicated skin and skin structure infections (cSSSI)AntibacterialHigh
- Treatment of MRSA infectionsAntimicrobialHigh
- Left-sided endocarditis (gram-positive)Infectious DiseaseModerate
- Staphylococcus aureus bacteremiaInfectious DiseaseHigh
- Vancomycin-resistant Enterococcus (VRE) infectionsInfectious DiseaseModerate
Contraindications
- Hypersensitivity to daptomycinAllergyHigh
- PneumoniaDisease SpecificHigh
- Concurrent high‑dose statin therapyDrug InteractionModerate
- Known hypersensitivity to daptomycinAllergyHigh
Adverse Effects
- Peripheral neuropathyNeurologicalUncommon
- Gastrointestinal upsetGastrointestinalCommon
- Skeletal muscle toxicity (myopathy/rhabdomyolysis)MusculoskeletalUncommon
- Gastrointestinal disturbancesGastrointestinalCommon
- Eosinophilic pneumoniaPulmonaryUncommon
- Myopathy / elevated CPKMusculoskeletalCommon
- Elevated liver enzymesHepaticUncommonIncrease in AST/ALT or other hepatic markers
- Infusion site reactionsLocalCommon
Drug Interactions
- TobramycinLow
- Statins (e.g., simvastatin, lovastatin)Moderate
- HMG-CoA reductase inhibitors (statins)Moderate
- WarfarinModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patients (<1 year)AgeAbsolute
- Renal impairment (CrCl <30 mL/min)RenalRelative
- Severe renal impairment (CrCl <30 mL/min)Organ ImpairmentRelative
- Pre-existing myopathy or elevated CKMusculoskeletalRelative
Regulatory Status
- European UnionApprovedApproved: Complicated skin and soft‑tissue infections, S. aureus bacteremia, Right‑sided endocarditisSame indications as US; marketed as Cubicin
- United StatesApprovedApproved: Complicated skin and soft‑tissue infections, S. aureus bacteremia, Right‑sided endocarditisPrescribed as intravenous infusion; dosing adjusted for renal function
- United KingdomApprovedApproved: Complicated skin and soft tissue infections, Staphylococcus aureus bacteremia and right-sided endocarditisApproved via MHRA; retained EU approval post-Brexit
FDA‑approved in 2003 (Cubicin) for S. aureus bacteremia, right‑sided endocarditis, and cSSSI; EMA approval for similar indications.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Daptomycin?
Daptomycin is a cyclic lipopeptide antibiotic administered intravenously for treatment of serious Gram‑positive infections such as complicated skin and soft‑tissue infections, bacteremia, and right‑sided endocarditis, including MRSA.
What is Daptomycin used for?
Daptomycin is educationally associated with: MRSA osteomyelitis, Complicated skin and skin structure infections (cSSSI), Treatment of MRSA infections, Left-sided endocarditis (gram-positive), Staphylococcus aureus bacteremia, Vancomycin-resistant Enterococcus (VRE) infections. Educational only — not medical advice.
How is Daptomycin administered?
Recorded routes of administration: Intravenous.
What are the potential side effects of Daptomycin?
Reported adverse effects include: Peripheral neuropathy, Gastrointestinal upset, Skeletal muscle toxicity (myopathy/rhabdomyolysis), Gastrointestinal disturbances, Eosinophilic pneumonia, Myopathy / elevated CPK, Elevated liver enzymes, Infusion site reactions. This list is not exhaustive — consult a qualified clinician.
Who should avoid Daptomycin?
Recorded contraindications: Hypersensitivity to daptomycin, Pneumonia, Concurrent high‑dose statin therapy, Known hypersensitivity to daptomycin. Consult a qualified clinician before use.