Ancestim
Also known as: Ancestim, PEG‑F, pegfilgrastim, r-metHuSCF, recombinant human stem cell factor, SCF, Stemgen
Source Ancestim at Peptiology
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Summary
Ancestim (pegfilgrastim) is a long‑acting, pegylated form of recombinant G‑CSF used to reduce the duration of severe neutropenia and the incidence of febrile neutropenia in patients receiving myelosuppressive chemotherapy.
Mechanism of Action
Binds to the G‑CSF receptor on myeloid progenitor cells, stimulating proliferation, differentiation and activation of neutrophil precursors, thereby increasing circulating neutrophil counts.
Routes of Administration
Goals & Uses
- Prevention of chemotherapy‑induced neutropeniaOncology Supportive CareHigh
- Peripheral blood progenitor cell (PBPC) mobilizationHematopoieticHigh
- Facilitation of dose‑dense chemotherapy regimensOncology Supportive CareModerate
- Rescue mobilization in patients failing G-CSF aloneHematopoieticModerate
- Augmentation of CD34+ cell yields for autologous transplantOncology/TransplantationHigh
Contraindications
- Asthma or reactive airway diseasePulmonaryHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Severe renal impairment (creatinine clearance <30 mL/min) without dose adjustment dataRenalModerate
- Known hypersensitivity to pegfilgrastim, filgrastim, or any excipientAllergyHigh
- History of severe allergic or anaphylactic reactions to ancestim or related compoundsHypersensitivityHigh
- Active systemic mastocytosisHematologicHigh
Adverse Effects
- Bone painMusculoskeletalCommon
- Injection site reactionsLocalCommon
- Urticaria / generalized pruritusDermatologicCommon
- FlushingVascularCommonWarmth and redness of the skin
- Injection‑site reactionsLocalCommon
- FeverSystemicUncommonElevated body temperature
- SplenomegalyHematologicUncommon
- Systemic allergic/anaphylactic reactionsImmunologicUncommon
Drug Interactions
- Myelosuppressive chemotherapy agentsLow
- Filgrastim (G-CSF)Low
- CorticosteroidsLow
- Antihistamines (H1 blockers)Low
- Concurrent corticosteroidsModerate
Population Constraints
- Patients with prior severe allergic reactions to SCFImmunologicAbsolute
- Pediatric patientsAgeRelative
- Patients with asthma or reactive airway diseasePulmonaryAbsolute
- Pregnant or breastfeeding womenReproductiveRelative
- Pediatric patients <2 years of ageAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionApprovedApproved: Prevention of chemotherapy‑induced neutropeniaEMA approval 2015; same indication as US.
- United StatesApprovedApproved: Reduction of incidence of infection in patients with non‑myeloid malignancies receiving myelosuppressive chemotherapyFDA approval 2015 as a biosimilar to Neulasta.
- United KingdomUnapprovedNot licensed in the UK; may have been available under named patient programs historically.
US FDA‑approved biosimilar to Neulasta (pegfilgrastim) in 2015; also approved in the EU and other jurisdictions for chemotherapy‑induced neutropenia.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Ancestim?
Ancestim (pegfilgrastim) is a long‑acting, pegylated form of recombinant G‑CSF used to reduce the duration of severe neutropenia and the incidence of febrile neutropenia in patients receiving myelosuppressive chemotherapy.
What is Ancestim used for?
Ancestim is educationally associated with: Prevention of chemotherapy‑induced neutropenia, Peripheral blood progenitor cell (PBPC) mobilization, Facilitation of dose‑dense chemotherapy regimens, Rescue mobilization in patients failing G-CSF alone, Augmentation of CD34+ cell yields for autologous transplant. Educational only — not medical advice.
How is Ancestim administered?
Recorded routes of administration: Subcutaneous.
What are the potential side effects of Ancestim?
Reported adverse effects include: Bone pain, Injection site reactions, Urticaria / generalized pruritus, Flushing, Injection‑site reactions, Fever, Splenomegaly, Systemic allergic/anaphylactic reactions. This list is not exhaustive — consult a qualified clinician.
Who should avoid Ancestim?
Recorded contraindications: Asthma or reactive airway disease, Pregnancy, Severe renal impairment (creatinine clearance <30 mL/min) without dose adjustment data, Known hypersensitivity to pegfilgrastim, filgrastim, or any excipient, History of severe allergic or anaphylactic reactions to ancestim or related compounds, Active systemic mastocytosis. Consult a qualified clinician before use.