Antipain
Also known as: [N-alpha-(N-(N-((S)-1-Carboxy-2-phenylethyl)carbamoyl)-arg-val)]-arginal, Ac-Leu-Leu-Arg-CHO, Antipain, Antipain dihydrochloride, Antipain hydrochloride, Leu-Arg-Arg-CHO, Leu-Leu-Arg-al, Protease inhibitor antipain
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Summary
Antipain is a synthetic peptide aldehyde (Leu‑Leu‑Arg‑CHO) used primarily as a laboratory tool to inhibit trypsin, chymotrypsin, and related proteases in biochemical assays.
Mechanism of Action
Reversible aldehyde inhibition of serine and cysteine proteases by forming a hemiacetal adduct at the active‑site serine/cysteine residue
Routes of Administration
No administration routes recorded yet.
Goals & Uses
- Investigation of protease roles in cellular processesResearch/pharmacologyModerate
- Inhibition of cathepsin B activityResearch/biochemistryHigh
- Inhibition of trypsin-like serine proteasesResearch/biochemistryHigh
- Protease inhibition in vitroResearch ToolHigh
- Protease inhibition in cell lysatesResearch/biochemistryHigh
Contraindications
No contraindications recorded yet.
Adverse Effects
- Cytotoxicity at high concentrationsIn Vitro ToxicityUncommon
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- Not for human or veterinary therapeutic useGeneralAbsolute
Regulatory Status
- European UnionUnapprovedResearch use only; not EMA approved
- United StatesUnapprovedNot approved for any clinical indication; available only as a research chemical.
- United KingdomUnapprovedResearch use only; not MHRA approved
Not approved for human therapeutic use; classified as a research chemical.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Antipain?
Antipain is a synthetic peptide aldehyde (Leu‑Leu‑Arg‑CHO) used primarily as a laboratory tool to inhibit trypsin, chymotrypsin, and related proteases in biochemical assays.
What is Antipain used for?
Antipain is educationally associated with: Investigation of protease roles in cellular processes, Inhibition of cathepsin B activity, Inhibition of trypsin-like serine proteases, Protease inhibition in vitro, Protease inhibition in cell lysates. Educational only — not medical advice.
What are the potential side effects of Antipain?
Reported adverse effects include: Cytotoxicity at high concentrations. This list is not exhaustive — consult a qualified clinician.