Chymostatin
Also known as: Chymostatin, Chymostatin A/B/C, Chymostatin mixture, N-[(S)-1-Carboxy-2-phenylethyl]-carbobenzyloxy-L-leucyl-L-leucyl-L-leucinal related, N‑acetyl‑L‑leucyl‑L‑phenylalanyl‑L‑phenylalaninal
Source Chymostatin at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Chymostatin is a peptide aldehyde that potently inhibits chymotrypsin and related serine proteases; it is employed primarily as a biochemical research tool.
Mechanism of Action
Reversible aldehyde-mediated inhibition of chymotrypsin-like serine proteases by forming a covalent hemiacetal with the active‑site serine residue
Routes of Administration
Goals & Uses
- Protease inhibition in biochemical assaysResearchHigh
- Protease inhibitor in cell lysis buffersResearch ToolHigh
- Inhibition of cathepsin G and chymaseResearch / BiochemistryModerate
- Study of apoptosis and autophagy pathwaysResearch / Cell BiologyModerate
- Inhibition of chymotrypsin-like serine proteasesResearch / BiochemistryHigh
- Inhibition of cysteine proteases (cathepsin B)Research / BiochemistryModerate
Contraindications
- Human or animal therapeutic administrationClinical UseHigh
Adverse Effects
- Cytotoxicity at high concentrationsIn Vitro ToxicityUncommon
- Non-specific protease inhibitionOff Target EffectCommon
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- Not for human useGeneral PopulationAbsolute
Regulatory Status
- European UnionUnapprovedResearch reagent only
- United StatesUnapprovedResearch reagent only; sold under laboratory-use exemptions, not as a drug
- United KingdomUnapprovedResearch reagent only
Not approved for clinical use; supplied as a research reagent.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Chymostatin?
Chymostatin is a peptide aldehyde that potently inhibits chymotrypsin and related serine proteases; it is employed primarily as a biochemical research tool.
What is Chymostatin used for?
Chymostatin is educationally associated with: Protease inhibition in biochemical assays, Protease inhibitor in cell lysis buffers, Inhibition of cathepsin G and chymase, Study of apoptosis and autophagy pathways, Inhibition of chymotrypsin-like serine proteases, Inhibition of cysteine proteases (cathepsin B). Educational only — not medical advice.
How is Chymostatin administered?
Recorded routes of administration: In Vitro, In Vitro (laboratory Use Only), Intraperitoneal, Intravenous.
What are the potential side effects of Chymostatin?
Reported adverse effects include: Cytotoxicity at high concentrations, Non-specific protease inhibition. This list is not exhaustive — consult a qualified clinician.
Who should avoid Chymostatin?
Recorded contraindications: Human or animal therapeutic administration. Consult a qualified clinician before use.