Aviptadil
Also known as: Phentolamine/VIP, RLF-100, RLF‑1, Synthetic VIP, Vasoactive Intestinal Peptide, VIP, ZYESAMI
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Summary
Synthetic 28‑amino‑acid peptide derived from vasoactive intestinal peptide, investigated for acute respiratory distress syndrome, COVID‑19–related lung injury, pulmonary hypertension and heart failure.
Mechanism of Action
Agonist of VPAC1 and VPAC2 receptors, producing vasodilation, bronchodilation, anti‑inflammatory and cytoprotective effects in lung and cardiovascular tissues
Routes of Administration
Goals & Uses
- COVID‑19 severe pneumoniaInfectiousModerate
- Erectile dysfunctionSexual HealthLow
- Sarcoidosis-related respiratory failureRespiratoryLow
- COVID-19-associated respiratory failureInfectious Disease / RespiratoryModerate
- Cytokine storm suppressionImmunomodulationModerate
- Pulmonary arterial hypertension (PAH)Cardiovascular / PulmonaryLow
- Acute Respiratory Distress Syndrome (ARDS)RespiratoryModerate
- Pulmonary hypertensionCardiovascularLow
Contraindications
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Known hypersensitivity to aviptadil or any peptide excipientsAllergyHigh
- Hypersensitivity to VIP or aviptadilAllergyHigh
- Uncontrolled cardiac arrhythmiasCardiovascularModerate
- Severe hypotension (SBP <90 mmHg)HemodynamicModerate
- Severe hypotensionCardiovascularHigh
Adverse Effects
- Injection site reactionsLocalUncommon
- HeadacheNeurologicUncommonPain in the head or upper neck
- HypotensionCardiovascularCommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- DiarrheaGastrointestinalUncommonLoose or frequent stools
Drug Interactions
- Antihypertensive agentsModerate
- Other vasodilators (e.g., nitroglycerin, ACE inhibitors)Moderate
- CYP‑metabolized drugsLow
- CorticosteroidsLow
- Vasopressors (e.g., norepinephrine)Low
- Phosphodiesterase-5 inhibitors (e.g., sildenafil)High
Population Constraints
- PregnancyReproductive SafetyRelative
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Pediatrics (<12 years)AgeRelative
- Patients with pre-existing severe hypotensionCardiovascularRelative
- Pregnant womenReproductiveRelative
- Elderly patients (≥65 years)Age RelatedRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization
- United StatesInvestigationalIND status; not FDA‑approved
- United KingdomUnapprovedNot licensed for clinical use
Received FDA Breakthrough Therapy Designation for treatment of COVID-19-associated respiratory failure. Not currently FDA-approved for any indication. Studied under Emergency Use Authorization context during COVID-19 pandemic. Orphan drug designation in EU for pulmonary arterial hypertension.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Aviptadil?
Synthetic 28‑amino‑acid peptide derived from vasoactive intestinal peptide, investigated for acute respiratory distress syndrome, COVID‑19–related lung injury, pulmonary hypertension and heart failure.
What is Aviptadil used for?
Aviptadil is educationally associated with: COVID‑19 severe pneumonia, Erectile dysfunction, Sarcoidosis-related respiratory failure, COVID-19-associated respiratory failure, Cytokine storm suppression, Pulmonary arterial hypertension (PAH), Acute Respiratory Distress Syndrome (ARDS), Pulmonary hypertension. Educational only — not medical advice.
How is Aviptadil administered?
Recorded routes of administration: Inhalation, Inhaled, Intravenous, Subcutaneous.
What are the potential side effects of Aviptadil?
Reported adverse effects include: Injection site reactions, Headache, Hypotension, Flushing, Tachycardia, Nausea, Diarrhea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Aviptadil?
Recorded contraindications: Pregnancy, Known hypersensitivity to aviptadil or any peptide excipients, Hypersensitivity to VIP or aviptadil, Uncontrolled cardiac arrhythmias, Severe hypotension (SBP <90 mmHg), Severe hypotension. Consult a qualified clinician before use.