Bradykinin
Also known as: BK, Bradykinin (1-9), H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH, Kallidin-9, Kinin, RPPGFSPFR
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Summary
Bradykinin is a nine‑amino‑acid endogenous peptide (RPPGFSPFR) that causes vasodilation, increased vascular permeability, smooth‑muscle contraction and pain via B1/B2 receptors.
Mechanism of Action
Activates B2 (and B1 under pathological conditions) G‑protein coupled receptors, stimulating phospholipase C, nitric oxide release and vasodilation; also mediates pain and increased vascular permeability.
Routes of Administration
Goals & Uses
- Wound healing / tissue repairRegenerativeLow
- Vasodilation / blood pressure reductionCardiovascularHigh
- Research tool for pain sensitizationNeuroscience / ResearchHigh
- Cardioprotection (ischemic preconditioning)CardiovascularModerate
- Provocative testing (bronchial / vascular)DiagnosticModerate
- pain sensitizationNeurologicalModerate
- induce vasodilationCardiovascularHigh
Contraindications
- Severe asthma / BronchospasmRespiratoryHigh
- History of bradykinin-mediated angioedemaAllergic / ImmunologicHigh
- PregnancyPopulationHighPotential fetal risk or insufficient safety data
- Hypotension / Hemodynamic instabilityCardiovascularHigh
- Severe hypotensionCardiovascularHigh
Adverse Effects
- Tachycardia (reflex)CardiovascularUncommon
- HypotensionCardiovascularCommonLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- BronchoconstrictionRespiratoryUncommon
- pain/flushingSensoryCommon
- Pain / Burning sensationNeurologicalCommon
- AngioedemaImmunologicRare
Drug Interactions
- NSAIDs (e.g., indomethacin, ibuprofen)Moderate
- Angiotensin Receptor Blockers (ARBs)Low
- NSAIDsLowMay increase renal risk in susceptible patients
- ACE inhibitorsModerate
- Nitrates / Nitric oxide donorsModerate
- ACE Inhibitors (e.g., enalapril, lisinopril)High
Population Constraints
- pediatric subjectsAgeRelative
- Elderly patientsAgeRelative
- Patients on ACE inhibitor therapyPharmacologicalAbsolute
- Pregnant womenReproductiveRelative
- Patients with hereditary angioedema (HAE)Genetic / ImmunologicAbsolute
- Asthmatic patientsRespiratoryRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization; available for investigational use.
- United StatesUnapprovedUsed only in research settings; not an FDA‑approved therapeutic.
- United KingdomUnapprovedNot approved by MHRA as a therapeutic. Research use only.
Bradykinin itself is not an approved therapeutic agent in any major jurisdiction. It is used as a research tool and in diagnostic/provocative testing contexts. Its antagonists (e.g., icatibant) and the bradykinin pathway are major therapeutic targets for hereditary angioedema.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Bradykinin?
Bradykinin is a nine‑amino‑acid endogenous peptide (RPPGFSPFR) that causes vasodilation, increased vascular permeability, smooth‑muscle contraction and pain via B1/B2 receptors.
What is Bradykinin used for?
Bradykinin is educationally associated with: Wound healing / tissue repair, Vasodilation / blood pressure reduction, Research tool for pain sensitization, Cardioprotection (ischemic preconditioning), Provocative testing (bronchial / vascular), pain sensitization, induce vasodilation. Educational only — not medical advice.
How is Bradykinin administered?
Recorded routes of administration: Inhalation, Intra Arterial, Intracerebroventricular, Intravenous, Topical.
What are the potential side effects of Bradykinin?
Reported adverse effects include: Tachycardia (reflex), Hypotension, Flushing, Bronchoconstriction, pain/flushing, Pain / Burning sensation, Angioedema. This list is not exhaustive — consult a qualified clinician.
Who should avoid Bradykinin?
Recorded contraindications: Severe asthma / Bronchospasm, History of bradykinin-mediated angioedema, Pregnancy, Hypotension / Hemodynamic instability, Severe hypotension. Consult a qualified clinician before use.