Cyclo(his-pro)
Also known as: CHP, Cyclo‑His‑Pro, Cyclo(His‑Pro), Cyclo(L-histidyl-L-proline), Histidyl-proline diketopiperazine, TRH dipeptide metabolite
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Summary
Cyclo(his-pro) (CHP) is a naturally occurring cyclic dipeptide composed of histidine and proline. It is investigated for anti‑inflammatory, antioxidant, neuroprotective, and anti‑aging activities, primarily as a dietary supplement or experimental therapeutic.
Mechanism of Action
Modulates inflammatory signaling (e.g., NF‑κB inhibition), enhances antioxidant defenses, and up‑regulates stress‑protein pathways such as Hsp70, contributing to neuro‑protective and anti‑aging effects.
Routes of Administration
Goals & Uses
- Prolactin inhibitionEndocrineModerate
- anti‑inflammatoryTherapeuticModerate
- NeuroprotectionNeurologyModerate
- anti‑agingWell‑beingLow
- Appetite and body weight regulationMetabolic / EndocrineLow
- Glucose homeostasisMetabolicLow
- Ethanol intake modulationNeurological / AddictionLow
Contraindications
- Hypersensitivity to cyclic dipeptidesAllergicHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
Adverse Effects
- Gastrointestinal upsetGastrointestinalUncommon
- Endocrine disruptionEndocrineUnknown
- NauseaGastrointestinalUnknownFeeling of sickness or urge to vomit
Drug Interactions
- None documentedLow
- Thyrotropin-releasing hormone (TRH) analoguesLow
- Dopaminergic agentsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric populationsAgeRelative
- Patients with prolactinomas or pituitary disordersEndocrineRelative
- ChildrenPediatricRelative
Regulatory Status
- European UnionUnapprovedMarketed as food supplement; no medicinal authorization.
- United StatesUnapprovedAvailable as dietary supplement; not FDA‑approved as drug.
- United KingdomUnapprovedNot authorized by MHRA; research use only.
Not approved as a pharmaceutical drug in major jurisdictions; marketed in some regions as a dietary supplement with limited clinical data.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Cyclo(his-pro)?
Cyclo(his-pro) (CHP) is a naturally occurring cyclic dipeptide composed of histidine and proline. It is investigated for anti‑inflammatory, antioxidant, neuroprotective, and anti‑aging activities, primarily as a dietary supplement or experimental therapeutic.
What is Cyclo(his-pro) used for?
Cyclo(his-pro) is educationally associated with: Prolactin inhibition, anti‑inflammatory, Neuroprotection, anti‑aging, Appetite and body weight regulation, Glucose homeostasis, Ethanol intake modulation. Educational only — not medical advice.
How is Cyclo(his-pro) administered?
Recorded routes of administration: Intranasal, Intraperitoneal, Intravenous, Oral.
What are the potential side effects of Cyclo(his-pro)?
Reported adverse effects include: Gastrointestinal upset, Endocrine disruption, Nausea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Cyclo(his-pro)?
Recorded contraindications: Hypersensitivity to cyclic dipeptides, Pregnancy. Consult a qualified clinician before use.