Cyclo(prolylglycyl)
Also known as: 2,5-diketopiperazine, 2,5-diketopiperazine-Pro-Gly, CPG, cyclo(L-prolyl-glycyl), cyclo(Pro-Gly), cyclo(Pro‑Gly), Pro-Gly DKP
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Summary
Cyclo(prolylglycyl) (cyclo(Pro‑Gly)) is a simple cyclic dipeptide formed from proline and glycine, commonly encountered as a natural product and used as a scaffold in peptide chemistry.
Mechanism of Action
Cyclo(Pro-Gly) is a diketopiperazine formed by cyclization of proline and glycine. It has been reported to modulate GABA-A receptors and interact with benzodiazepine binding sites, potentially exhibiting anxiolytic and neuroprotective properties. It may also influence dopaminergic and serotonergic neurotransmission at the CNS level.
Routes of Administration
Goals & Uses
- NeuroprotectionNeurologyLow
- Anxiolytic effectNeuropsychiatricLow
- Nootropic / cognitive enhancementCognitiveLow
- AnticonvulsantNeurologicalLow
Contraindications
- Known hypersensitivity to proline or glycine derivativesAllergyHigh
Adverse Effects
- Unknown systemic effectsGeneralUnknown
Drug Interactions
- BenzodiazepinesLow
- GABAergic agentsLow
Population Constraints
- Pregnant or lactating individualsReproductiveRelative
- Pediatric populationsAgeRelative
- ElderlyAgeRelative
Regulatory Status
- European UnionUnapprovedNot EMA-approved; no IMPD or clinical trial registration identified.
- United StatesUnapprovedNot FDA-approved; no IND or clinical trial registration identified.
- United KingdomUnapprovedNot MHRA-approved; research compound only.
Not approved by any major regulatory agency (FDA, EMA, MHRA) for any therapeutic indication. Investigated exclusively in preclinical research settings.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Cyclo(prolylglycyl)?
Cyclo(prolylglycyl) (cyclo(Pro‑Gly)) is a simple cyclic dipeptide formed from proline and glycine, commonly encountered as a natural product and used as a scaffold in peptide chemistry.
What is Cyclo(prolylglycyl) used for?
Cyclo(prolylglycyl) is educationally associated with: Neuroprotection, Anxiolytic effect, Nootropic / cognitive enhancement, Anticonvulsant. Educational only — not medical advice.
How is Cyclo(prolylglycyl) administered?
Recorded routes of administration: Intraperitoneal, Intravenous, Oral.
What are the potential side effects of Cyclo(prolylglycyl)?
Reported adverse effects include: Unknown systemic effects. This list is not exhaustive — consult a qualified clinician.
Who should avoid Cyclo(prolylglycyl)?
Recorded contraindications: Known hypersensitivity to proline or glycine derivatives. Consult a qualified clinician before use.