DPDPE
Also known as: [2,5]-enkephalin, [D-Pen2,D-Pen5]-Enkephalin, [D-Pen2,D-Pen5]enkephalin, Cyclic DPDPE, D-Pen-enkephalin, D-Pen2,D-Pen5-Enkephalin, DPDPE
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Summary
DPDPE ([D-Pen2,D-Pen5]enkephalin) is a synthetic, highly selective delta-opioid receptor agonist used primarily in preclinical research to study analgesia, mood modulation, and opioid receptor pharmacology.
Mechanism of Action
Selective agonist of the delta-opioid receptor (DOR), coupling to Gi/o proteins to inhibit adenylate cyclase and modulate neuronal signaling
Routes of Administration
Goals & Uses
- Analgesia (preclinical)Pain / NociceptionHigh
- Cardioprotection (preclinical)Cardiovascular ResearchModerate
- analgesia researchPainModerate
- Mood and antidepressant effects (preclinical)Neuropsychiatry ResearchModerate
- Neuroprotection (preclinical)Neuroscience ResearchModerate
- Delta-opioid receptor characterizationResearch / PharmacologyHigh
- neuropsychiatric studiesMoodLow
- opioid receptor selectivity profilingPharmacologyHigh
Contraindications
- Known hypersensitivity to enkephalin analoguesAllergy/ImmunologyHigh
- Human therapeutic useRegulatory/safetyHigh
Adverse Effects
- Convulsions/SeizuresNeurologicalUncommon
- Cardiovascular effectsCardiovascularUnknown
- ConstipationGastrointestinalUnknownReduced bowel frequency or difficulty passing stool
- Tolerance developmentPharmacologicalCommon
- Respiratory depressionRespiratoryUnknown
- SedationCNSCommon
Drug Interactions
- CNS depressantsModerate
- Mu-opioid receptor agonists (e.g., morphine)Moderate
- Naltrindole (delta-opioid antagonist)High
- Other opioid agonistsModerate
Population Constraints
- HumansRegulatory / SafetyAbsolute
- Pregnant or lactating animalsReproductiveRelative
- Human subjectsRegulatory/SafetyAbsolute
Regulatory Status
- European UnionInvestigationalNo marketing authorization; used in scientific research.
- United StatesInvestigationalResearch chemical, not FDA-approved.
- United KingdomUnapprovedNot approved by MHRA; controlled under UK drug regulations as an opioid analogue for research purposes only.
Not approved for human therapeutic use; classified as a research chemical.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is DPDPE?
DPDPE ([D-Pen2,D-Pen5]enkephalin) is a synthetic, highly selective delta-opioid receptor agonist used primarily in preclinical research to study analgesia, mood modulation, and opioid receptor pharmacology.
What is DPDPE used for?
DPDPE is educationally associated with: Analgesia (preclinical), Cardioprotection (preclinical), analgesia research, Mood and antidepressant effects (preclinical), Neuroprotection (preclinical), Delta-opioid receptor characterization, neuropsychiatric studies, opioid receptor selectivity profiling. Educational only — not medical advice.
How is DPDPE administered?
Recorded routes of administration: Intracerebroventricular, Intrathecal, Intravenous, Subcutaneous.
What are the potential side effects of DPDPE?
Reported adverse effects include: Convulsions/Seizures, Cardiovascular effects, Constipation, Tolerance development, Respiratory depression, Sedation. This list is not exhaustive — consult a qualified clinician.
Who should avoid DPDPE?
Recorded contraindications: Known hypersensitivity to enkephalin analogues, Human therapeutic use. Consult a qualified clinician before use.