CRH and Stress-Axis Peptides
2 compounds in this family, each with its recorded mechanism, routes of administration, safety notes and references to published literature.
- CorticorelinCorticorelin acetate (also known as Corticorelin, Acthrel) is a synthetic analogue of human corticotropin‑releasing hormone (CRH) administered by injection. It is prescribed primarily to reduce peritumoral brain edema in patients with malignant brain tumors, with the aim of lowering the dose of corticosteroids such as dexamethasone and thereby limiting steroid‑related toxicity.
- Urocortin-2Urocortin‑2 (Ucn‑2) is a 38‑amino‑acid peptide of the corticotropin‑releasing factor family. It signals chiefly through the type‑2 corticotropin‑releasing hormone receptor (CRHR2) and is being explored for metabolic and cardiovascular uses, such as preserving lean mass during weight loss and protecting the heart from failure‑related injury. The compound is not approved for any therapeutic indication and is currently studied only in research settings, typically administered by injection.