Nerve Growth Factor
Also known as: Beta-NGF, beta‑NGF, Cenegermin, Nerve Growth Factor, NGF, NGF-beta, Oxervate, rhNGF
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Summary
Recombinant human Nerve Growth Factor (NGF) is a 120‑aa dimeric protein that supports the growth and maintenance of sympathetic and sensory neurons. Investigated for neurodegenerative disorders, ocular surface disease, and peripheral neuropathies.
Mechanism of Action
Binds high‑affinity TrkA and low‑affinity p75NTR receptors, activating downstream MAPK, PI3K/Akt and PLCγ pathways to promote neuronal survival, differentiation and axonal growth.
Routes of Administration
Goals & Uses
- Neuroprotection in Alzheimer's diseaseNeurologyLow
- Dry eye diseaseOphthalmologyModerate
- Wound healing / corneal regenerationOphthalmology / DermatologyModerate
- NeuroprotectionNeurologyModerate
- Peripheral neuropathy treatmentNeurologyLow
- Treatment of neurotrophic keratitisOphthalmologyHigh
- NeuroregenerationFunctional RecoveryModerate
Contraindications
- Active malignancyOncologyHighUse caution or avoid depending on agent and context
- Hypersensitivity to NGF or formulation componentsAllergyHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Known hypersensitivity to recombinant NGF productAllergyHigh
- Active ocular infectionOphthalmologyHigh
Adverse Effects
- Systemic hyperalgesia / myalgiaNeurological / MusculoskeletalCommon
- Hypersensitivity reactionsImmunologicRare
- Ocular hyperemiaOphthalmologicCommon
- Injection site painLocalCommonPain at the injection site
- Corneal deposits (topical)OphthalmologicUncommon
- Flu‑like syndromeSystemicUncommon
- Eye pain / foreign body sensationOphthalmologicCommon
Drug Interactions
- Anti-NGF antibodies (tanezumab, fasinumab)High
- NSAIDs / AnalgesicsModerate
- Other neurotrophic agents (e.g., BDNF mimetics)Moderate
- Immunosuppressants (e.g., cyclosporine)Low
- Corticosteroids (topical ocular)Moderate
Population Constraints
- Pediatric patientsAgeRelative
- Patients with chronic pain conditionsComorbidityRelative
- Immunocompromised patientsImmunologicRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionInvestigationalClinical trial authorization required; not marketed.
- United StatesInvestigationalInvestigational New Drug (IND) applications for Alzheimer's and ocular surface disease.
- United KingdomInvestigationalSubject to MHRA clinical trial approval only.
Not approved for any indication in major jurisdictions; used under clinical trial protocols or compassionate use programs.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Nerve Growth Factor?
Recombinant human Nerve Growth Factor (NGF) is a 120‑aa dimeric protein that supports the growth and maintenance of sympathetic and sensory neurons. Investigated for neurodegenerative disorders, ocular surface disease, and peripheral neuropathies.
What is Nerve Growth Factor used for?
Nerve Growth Factor is educationally associated with: Neuroprotection in Alzheimer's disease, Dry eye disease, Wound healing / corneal regeneration, Neuroprotection, Peripheral neuropathy treatment, Treatment of neurotrophic keratitis, Neuroregeneration. Educational only — not medical advice.
How is Nerve Growth Factor administered?
Recorded routes of administration: Intranasal, Intravenous, Intravitreal, Subcutaneous, Topical, Topical Ocular.
What are the potential side effects of Nerve Growth Factor?
Reported adverse effects include: Systemic hyperalgesia / myalgia, Hypersensitivity reactions, Ocular hyperemia, Injection site pain, Corneal deposits (topical), Flu‑like syndrome, Eye pain / foreign body sensation. This list is not exhaustive — consult a qualified clinician.
Who should avoid Nerve Growth Factor?
Recorded contraindications: Active malignancy, Hypersensitivity to NGF or formulation components, Pregnancy, Known hypersensitivity to recombinant NGF product, Active ocular infection. Consult a qualified clinician before use.