Virginiamycin M1
Also known as: Ostreogrycin A, Pristinamycin IIA, Streptogramin A (virginiamycin type), Streptogramin A component, Virginiamycin M, Virginiamycin M1, VM1
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Summary
Virginiamycin M1 is the streptogramin A component of the veterinary antibiotic virginiamycin, a peptide‑derived inhibitor of bacterial protein synthesis used mainly as a feed additive and studied for human antibacterial applications.
Mechanism of Action
Binds to the 50S ribosomal subunit, inhibiting peptide chain elongation; synergistic with streptogramin B component
Routes of Administration
Goals & Uses
- Prevention of necrotic enteritis in poultryVeterinary / Infectious DiseaseModerate
- Growth promotion in livestockVeterinary / AgriculturalHigh
- Antibacterial activityInfectious DiseaseModerate
- Treatment of Gram-positive bacterial infectionsAntimicrobialModerate
Contraindications
- Known hypersensitivity to streptograminsAllergyHigh
- Use in animals intended for human consumption during withdrawal periodVeterinary RegulatoryHigh
- Hypersensitivity to streptograminsAllergyHigh
Adverse Effects
- Selection for streptogramin-resistant enterococci (VRE cross-resistance)Antimicrobial ResistanceUnknown
- Gastrointestinal upsetGastrointestinalCommon
- Gastrointestinal irritationGastrointestinalUncommon
Drug Interactions
- Virginiamycin S1 (streptogramin B component)Low
- Virginiamycin S1Moderate
Population Constraints
- EU livestockGeographic / RegulatoryAbsolute
- Pregnant or lactating womenReproductiveRelative
- Human useGeneral PopulationRelative
Regulatory Status
- European UnionWithdrawnWithdrawn from feed additive market due to resistance concerns.
- United StatesUnapprovedNot approved for human use; experimental investigations only.
- United KingdomUnapprovedNo human approval; limited veterinary use under strict regulation.
Approved for use as a veterinary feed additive in some countries; not approved for human therapy in the US and EU; withdrawn from the EU feed market in 2006 due to resistance concerns.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Virginiamycin M1?
Virginiamycin M1 is the streptogramin A component of the veterinary antibiotic virginiamycin, a peptide‑derived inhibitor of bacterial protein synthesis used mainly as a feed additive and studied for human antibacterial applications.
What is Virginiamycin M1 used for?
Virginiamycin M1 is educationally associated with: Prevention of necrotic enteritis in poultry, Growth promotion in livestock, Antibacterial activity, Treatment of Gram-positive bacterial infections. Educational only — not medical advice.
How is Virginiamycin M1 administered?
Recorded routes of administration: Oral.
What are the potential side effects of Virginiamycin M1?
Reported adverse effects include: Selection for streptogramin-resistant enterococci (VRE cross-resistance), Gastrointestinal upset, Gastrointestinal irritation. This list is not exhaustive — consult a qualified clinician.
Who should avoid Virginiamycin M1?
Recorded contraindications: Known hypersensitivity to streptogramins, Use in animals intended for human consumption during withdrawal period, Hypersensitivity to streptogramins. Consult a qualified clinician before use.