acetylleucyl-leucyl-norleucinal
Also known as: Ac-Leu-Leu-Nle-CHO, Ac-LLnL, Ac-LLnL-CHO, Acetyl-Leu-Leu-norleucinal, ALLN, Calpain Inhibitor I, MG-101, N-Acetyl-Leu-Leu-Nle-CHO
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Summary
Acetyl-Leu-Leu-norleucinal is a synthetic peptide aldehyde used experimentally to inhibit serine proteases in biochemical assays.
Mechanism of Action
Reversible aldehyde inhibitor of serine proteases (e.g., trypsin, chymotrypsin, elastase)
Routes of Administration
Goals & Uses
- Proteasome inhibition (research)Ubiquitin Proteasome PathwayHigh
- NF-κB pathway studySignal Transduction ResearchModerate
- Cathepsin inhibition (research)Lysosomal Protease InhibitionModerate
- Proteasome inhibition in vitroResearch ToolModerate
- Protease inhibitionResearch ToolHigh
- Apoptosis researchCell Death BiologyModerate
- Apoptosis induction studiesResearch ToolModerate
- Calpain inhibition (research)Protease InhibitionHigh
Contraindications
- Human therapeutic useRegulatory/safetyHigh
Adverse Effects
- Off-target protease inhibitionPharmacologicalCommon
- ER stress inductionCell BiologyUncommon
- CytotoxicityCell ViabilityCommon
Drug Interactions
- Other proteasome inhibitors (e.g., MG-132, bortezomib)High
- Cysteine protease substrates/assaysModerate
Population Constraints
- In vivo / human useSafetyAbsolute
Regulatory Status
- European UnionUnapprovedNo marketing authorization in the European Union.
- United StatesUnapprovedNot an FDA‑approved therapeutic; supplied as a research chemical.
- United KingdomUnapprovedNot licensed for clinical use in the United Kingdom.
Not approved for human therapeutic use; classified as a research chemical.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is acetylleucyl-leucyl-norleucinal?
Acetyl-Leu-Leu-norleucinal is a synthetic peptide aldehyde used experimentally to inhibit serine proteases in biochemical assays.
What is acetylleucyl-leucyl-norleucinal used for?
acetylleucyl-leucyl-norleucinal is educationally associated with: Proteasome inhibition (research), NF-κB pathway study, Cathepsin inhibition (research), Proteasome inhibition in vitro, Protease inhibition, Apoptosis research, Apoptosis induction studies, Calpain inhibition (research). Educational only — not medical advice.
How is acetylleucyl-leucyl-norleucinal administered?
Recorded routes of administration: In Vitro, In Vitro (cell Culture), Intraperitoneal, Intraperitoneal (animal Studies Only), Intravenous, Subcutaneous.
What are the potential side effects of acetylleucyl-leucyl-norleucinal?
Reported adverse effects include: Off-target protease inhibition, ER stress induction, Cytotoxicity. This list is not exhaustive — consult a qualified clinician.
Who should avoid acetylleucyl-leucyl-norleucinal?
Recorded contraindications: Human therapeutic use. Consult a qualified clinician before use.