Adrenomedullin
Also known as: ADM, Adrecizumab target peptide, Adrenomedullin-2, Adrenomedullin‑1, AM, hAM(1-52), Peptide hormone adrenomedullin, Proadrenomedullin-derived peptide
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Summary
Adrenomedullin is a 52‑amino‑acid endogenous peptide with strong vasodilatory, angiogenic, and anti‑inflammatory properties, investigated for cardiovascular, renal, and wound‑healing applications.
Mechanism of Action
Binds to the calcitonin receptor-like receptor (CLR) coupled with RAMP2/3, activating adenylate cyclase and increasing cAMP, leading to potent vasodilation, angiogenesis, and natriuresis.
Routes of Administration
Goals & Uses
- Heart failureCardiovascularLow
- Preeclampsia preventionObstetricsLow
- Renal protectionRenalLow
- Sepsis therapyCritical CareModerate
- Vasodilation / Hypotensive effectCardiovascularHigh
- Inflammatory bowel diseaseGastroenterologyModerate
- Pulmonary hypertensionCardiovascularModerate
- Septic shock treatmentCritical CareModerate
- AngiogenesisTissue RepairModerate
- Cardioprotection / Heart failureCardiovascularModerate
- VasodilationCardiovascular SupportModerate
Contraindications
- Severe hypotension / HypovolemiaCardiovascularHigh
- Known hypersensitivity to adrenomedullinImmunologicalHigh
- Hypertrophic obstructive cardiomyopathyCardiovascularModerate
- Severe aortic stenosisCardiovascularHigh
- Severe hypotensionCardiovascularHigh
Adverse Effects
- Injection site reactionsLocalUncommon
- HeadacheNeurologicUncommonPain in the head or upper neck
- Flushing / Facial flushingDermatologicalCommon
- HypotensionCardiovascularCommonLow blood pressure
- FlushingVascularUncommonWarmth and redness of the skin
- TachycardiaCardiovascularCommonAbnormally fast heart rate
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- Tachycardia / Reflex tachycardiaCardiovascularCommon
Drug Interactions
- NitratesModerate
- Phosphodiesterase inhibitors (e.g., sildenafil)Moderate
- Antihypertensive agentsModerate
- Beta‑blockersLow
- Other vasodilators (e.g., nitroglycerin)Moderate
- Vasopressors (e.g., norepinephrine)Moderate
- DiureticsLowMay worsen dehydration or electrolyte imbalance
Population Constraints
- PregnancyReproductive SafetyRelative
- Hepatic impairmentOrgan FunctionRelative
- Renal impairmentOrgan ImpairmentRelative
- Severe renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization.
- United StatesUnapprovedInvestigational use only in clinical trials.
- United KingdomInvestigationalNo MHRA approval. Participates in multinational investigational trials.
Not approved as a therapeutic agent in any jurisdiction; studied in preclinical and early‑phase clinical trials.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Adrenomedullin?
Adrenomedullin is a 52‑amino‑acid endogenous peptide with strong vasodilatory, angiogenic, and anti‑inflammatory properties, investigated for cardiovascular, renal, and wound‑healing applications.
What is Adrenomedullin used for?
Adrenomedullin is educationally associated with: Heart failure, Preeclampsia prevention, Renal protection, Sepsis therapy, Vasodilation / Hypotensive effect, Inflammatory bowel disease, Pulmonary hypertension, Septic shock treatment, Angiogenesis, Cardioprotection / Heart failure, Vasodilation. Educational only — not medical advice.
How is Adrenomedullin administered?
Recorded routes of administration: Intraperitoneal, Intravenous, Subcutaneous.
What are the potential side effects of Adrenomedullin?
Reported adverse effects include: Injection site reactions, Headache, Flushing / Facial flushing, Hypotension, Flushing, Tachycardia, Nausea, Tachycardia / Reflex tachycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Adrenomedullin?
Recorded contraindications: Severe hypotension / Hypovolemia, Known hypersensitivity to adrenomedullin, Hypertrophic obstructive cardiomyopathy, Severe aortic stenosis, Severe hypotension. Consult a qualified clinician before use.