Intermedine
Also known as: ADM2, Adrenomedullin 2, Intermedin, Melanocyte-stimulating hormone (intermediate lobe), Pars intermedia MSH, β-MSH (in some species)
Source Intermedine at Peptiology
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Summary
Intermedine (also known as adrenomedullin‑2 or intermedin) is a 53‑amino‑acid endogenous peptide of the calcitonin family that acts as a vasodilator and has cardioprotective and metabolic effects in pre‑clinical studies.
Mechanism of Action
Activates the calcitonin receptor-like receptor (CLR) complexed with RAMP2 or RAMP3, increasing intracellular cAMP and causing vasodilation and cardioprotective signaling
Routes of Administration
Goals & Uses
- Heart failure treatmentCardiovascularLow
- Energy homeostasis / Feeding behaviorMetabolicLow
- Metabolic regulationEndocrineLow
- Melanogenesis / Skin PigmentationPigmentationModerate
- Cardiovascular modulationCardiovascularLow
- Anti-inflammatory effectsInflammationLow
- VasodilationCardiovascular SupportModerate
Contraindications
- Known hypersensitivity to melanocortin peptidesAllergy/ImmunologyHigh
- Melanoma or pigmented lesion historyOncologyHigh
Adverse Effects
- Injection site reactionsLocalUnknown
- HeadacheNeurologicUnknownPain in the head or upper neck
- HypotensionCardiovascularUnknownLow blood pressure
- Cardiovascular effects (blood pressure changes)CardiovascularUnknown
- NauseaGastrointestinalUnknownFeeling of sickness or urge to vomit
- HyperpigmentationDermatologicUnknown
Drug Interactions
- Other melanocortin receptor agonists/antagonistsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Patients with active malignancyOncologyRelative
- Pediatric populationsAgeRelative
Regulatory Status
- European UnionUnapprovedNo EMA approval
- United StatesUnapprovedNo FDA approval
- United KingdomUnapprovedNo MHRA approval
Not approved for any therapeutic indication; used only in experimental and pre‑clinical settings.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Intermedine?
Intermedine (also known as adrenomedullin‑2 or intermedin) is a 53‑amino‑acid endogenous peptide of the calcitonin family that acts as a vasodilator and has cardioprotective and metabolic effects in pre‑clinical studies.
What is Intermedine used for?
Intermedine is educationally associated with: Heart failure treatment, Energy homeostasis / Feeding behavior, Metabolic regulation, Melanogenesis / Skin Pigmentation, Cardiovascular modulation, Anti-inflammatory effects, Vasodilation. Educational only — not medical advice.
How is Intermedine administered?
Recorded routes of administration: Intraperitoneal, Intravenous, Subcutaneous.
What are the potential side effects of Intermedine?
Reported adverse effects include: Injection site reactions, Headache, Hypotension, Cardiovascular effects (blood pressure changes), Nausea, Hyperpigmentation. This list is not exhaustive — consult a qualified clinician.
Who should avoid Intermedine?
Recorded contraindications: Known hypersensitivity to melanocortin peptides, Melanoma or pigmented lesion history. Consult a qualified clinician before use.