Salmon calcitonin
Also known as: Calcimar, Calsynar, Fortical, Miacalcin, Salcatonin, Salmon calcitonin, sCT
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Summary
Salmon calcitonin is a 31‑amino‑acid peptide used to treat osteoporosis, hypercalcemia of malignancy, and Paget disease of bone. It is administered by subcutaneous injection or intranasal spray.
Mechanism of Action
Activates the calcitonin receptor on osteoclasts, inhibiting bone resorption and decreasing serum calcium levels.
Routes of Administration
Goals & Uses
- Postmenopausal osteoporosisBone MetabolismModerate
- Osteoporosis treatmentBone MetabolismHigh
- Analgesia in bone painPain ManagementModerate
- Paget disease of boneBone RemodelingModerate
- Treatment of Paget's disease of boneBone MetabolismHigh
- Treatment of hypercalcemiaMineral HomeostasisHigh
- Hypercalcemia of malignancyCalcium RegulationHigh
- Prevention of immobilization hypercalcemiaMineral HomeostasisModerate
Contraindications
- Severe hypocalcemiaElectrolyte DisorderModerate
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Hypersensitivity to salmon calcitoninAllergy/ImmunologyHigh
- HypocalcemiaElectrolyte DisorderHigh
- Hypersensitivity to salmon calcitonin or formulation excipientsAllergyHigh
Adverse Effects
- Nasal irritationLocal/NasalCommon
- Facial flushingCardiovascular/DermatologicCommon
- Injection site painLocalCommonPain at the injection site
- FlushingVascularCommonWarmth and redness of the skin
- Rhinitis and nasal symptomsENTCommon
- Nausea and vomitingGastrointestinalCommon
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- HypocalcemiaMetabolicUncommon
- Malignancy (long-term use)OncologyRare
- VomitingGastrointestinalCommonForceful expulsion of stomach contents
- TachyphylaxisPharmacodynamicCommon
Drug Interactions
- BisphosphonatesModerate
- Calcium supplements / Vitamin DLow
- Calcium supplementsLow
- LithiumModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeAbsolute
- Long‑term therapy (>2 years)DurationRelative
- Lactating womenReproductiveRelative
- Patients with History of MalignancyOncologyRelative
Regulatory Status
- European UnionApprovedApproved: osteoporosis, hypercalcemia, Paget diseaseAvailable as nasal spray (Calcimar) and injection.
- United StatesApprovedApproved: osteoporosis, hypercalcemia of malignancy, Paget disease of bonePrescription injectable (Miacalcin) and nasal spray.
- United KingdomApprovedApproved: osteoporosis, hypercalcemia, Paget diseasePrescription use; same formulations as EU.
Approved in the US, EU and UK for osteoporosis, hypercalcemia, and Paget disease. Available as injectable (e.g., Miacalcin) and nasal spray formulations.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Salmon calcitonin?
Salmon calcitonin is a 31‑amino‑acid peptide used to treat osteoporosis, hypercalcemia of malignancy, and Paget disease of bone. It is administered by subcutaneous injection or intranasal spray.
What is Salmon calcitonin used for?
Salmon calcitonin is educationally associated with: Postmenopausal osteoporosis, Osteoporosis treatment, Analgesia in bone pain, Paget disease of bone, Treatment of Paget's disease of bone, Treatment of hypercalcemia, Hypercalcemia of malignancy, Prevention of immobilization hypercalcemia. Educational only — not medical advice.
How is Salmon calcitonin administered?
Recorded routes of administration: Intramuscular, Intranasal, Intravenous, Nasal, Subcutaneous.
What are the potential side effects of Salmon calcitonin?
Reported adverse effects include: Nasal irritation, Facial flushing, Injection site pain, Flushing, Rhinitis and nasal symptoms, Nausea and vomiting, Nausea, Hypocalcemia, Malignancy (long-term use), Vomiting, Tachyphylaxis. This list is not exhaustive — consult a qualified clinician.
Who should avoid Salmon calcitonin?
Recorded contraindications: Severe hypocalcemia, Pregnancy, Hypersensitivity to salmon calcitonin, Hypocalcemia, Hypersensitivity to salmon calcitonin or formulation excipients. Consult a qualified clinician before use.