Bombesin
Also known as: BBN, BN, Bombesin, Frog bombesin, Gastrin-releasing peptide amphibian homolog, Litorin-related peptide
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Summary
Bombesin is a 14‑amino‑acid amphibian peptide that mimics mammalian gastrin‑releasing peptide. It is used experimentally for studying GRPR signaling and as a targeting moiety in radiopharmaceuticals for cancer imaging and therapy.
Mechanism of Action
Binds gastrin-releasing peptide receptor (GRPR) and neuromedin‑B receptor, triggering intracellular calcium mobilization and downstream release of gastrin, cholecystokinin and growth‑factor signaling.
Routes of Administration
Goals & Uses
- Appetite suppression / satiety signaling researchMetabolic / NeuroscienceModerate
- Targeted drug delivery vehicleOncology / Drug DeliveryLow
- Research tool for gastrointestinal hormone studiesBasic ResearchHigh
- GRPR‑directed radionuclide therapyTherapeutic TargetingModerate
- Cancer receptor imaging (prostate, breast, SCLC)Oncology / Nuclear MedicineModerate
- Thermoregulation researchNeuroscienceLow
- GI hormone secretion stimulationGastroenterologyModerate
- GRPR‑targeted PET imagingDiagnostic ImagingModerate
Contraindications
- Severe peptic ulcer diseaseGastroenterologyModerate
- Active GI obstruction or ileusGastroenterologyModerate
- Hypersensitivity to bombesin or related peptidesAllergy / ImmunologyHigh
Adverse Effects
- AnaphylaxisImmunologicRareSevere life-threatening allergic reaction
- Injection site reactionsLocalCommon
- HypotensionCardiovascularUnknownLow blood pressure
- FlushingVascularUnknownWarmth and redness of the skin
- Nausea and vomitingGastrointestinalCommon
- NauseaGastrointestinalUnknownFeeling of sickness or urge to vomit
- Abdominal crampingGastrointestinalCommon
Drug Interactions
- AnticholinergicsLow
- Proton pump inhibitors / H2 blockersLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric populationsAgeRelative
- Pediatric useAgeRelative
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionUnapprovedNo marketing authorization; used in clinical trials.
- United StatesUnapprovedInvestigational use only under IND.
- United KingdomUnapprovedResearch use only.
Not approved for any therapeutic indication; employed only in pre‑clinical and early clinical research settings.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Bombesin?
Bombesin is a 14‑amino‑acid amphibian peptide that mimics mammalian gastrin‑releasing peptide. It is used experimentally for studying GRPR signaling and as a targeting moiety in radiopharmaceuticals for cancer imaging and therapy.
What is Bombesin used for?
Bombesin is educationally associated with: Appetite suppression / satiety signaling research, Targeted drug delivery vehicle, Research tool for gastrointestinal hormone studies, GRPR‑directed radionuclide therapy, Cancer receptor imaging (prostate, breast, SCLC), Thermoregulation research, GI hormone secretion stimulation, GRPR‑targeted PET imaging. Educational only — not medical advice.
How is Bombesin administered?
Recorded routes of administration: Intracerebroventricular, Intranasal, Intravenous, Subcutaneous.
What are the potential side effects of Bombesin?
Reported adverse effects include: Anaphylaxis, Injection site reactions, Hypotension, Flushing, Nausea and vomiting, Nausea, Abdominal cramping. This list is not exhaustive — consult a qualified clinician.
Who should avoid Bombesin?
Recorded contraindications: Severe peptic ulcer disease, Active GI obstruction or ileus, Hypersensitivity to bombesin or related peptides. Consult a qualified clinician before use.