Insulin human
Also known as: Human insulin, Humulin, INS, Insulin human, Myxredlin, Novolin, Regular insulin
Source Insulin human at Peptiology
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Summary
Recombinant human insulin used to replace deficient endogenous insulin in diabetes mellitus, controlling blood glucose levels.
Mechanism of Action
Binds insulin receptor → tyrosine kinase activation → PI3K/Akt pathway → ↑ glucose uptake, glycogen synthesis, protein synthesis, and lipid synthesis; suppresses hepatic gluconeogenesis.
Routes of Administration
Goals & Uses
- Gestational diabetes managementObstetricsHigh
- Glycemic control in type 2 diabetesMetabolicHigh
- Glycemic control in type 1 diabetesMetabolic / EndocrineHigh
- Glycemic control in type 1 diabetes mellitusEndocrine / MetabolicHigh
- Management of diabetic ketoacidosis (DKA)Emergency MedicineHigh
- Perioperative glucose controlSurgical / Critical CareHigh
- Hyperkalemia treatmentElectrolyte ManagementHigh
- Glycemic control in type 2 diabetes mellitusEndocrine / MetabolicHigh
Contraindications
- Hypokalemia (uncorrected)ElectrolyteModerate
- Hypersensitivity to insulin human or excipientsImmunologicHigh
- Hypersensitivity to insulin or excipientsAllergicModerate
- Hypoglycemia (active episode)MetabolicHigh
- HypoglycemiaMetabolicHigh
Adverse Effects
- HypokalemiaElectrolyteUncommon
- HypoglycemiaMetabolicCommonAbnormally low blood glucose
- Peripheral edemaFluid BalanceUncommonSwelling of the arms or legs
- Allergic reactionsImmunologicalRare
- Injection site reactions (lipohypertrophy, lipoatrophy)Local / DermatologicCommon
- Anaphylaxis / systemic allergyImmunologicRare
- Injection‑site reactionsLocalCommon
- Weight gainMetabolicCommonIncrease in body weight
Drug Interactions
- Thiazolidinediones (e.g., pioglitazone)Moderate
- Beta-blockers (non-selective)Moderate
- Beta‑blockersModerate
- Salicylates (high dose)Low
- AlcoholModerate
- CorticosteroidsModerate
- MAO inhibitorsModerate
- ACE inhibitorsLow
- Thiazide diureticsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Hepatic impairmentOrgan FunctionRelative
- Renal impairmentOrgan ImpairmentRelative
- Elderly patientsAgeRelative
- Pediatrics (<2 years)AgeRelative
- Pediatric patients (neonates)AgeRelative
Regulatory Status
- European UnionApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitusEMA approval for recombinant human insulin products.
- United StatesApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetesMultiple formulations approved by FDA.
- United KingdomApprovedApproved: type 1 diabetes mellitus, type 2 diabetes mellitusMHRA approved; same indications as EU.
Approved worldwide for type 1 and type 2 diabetes; multiple formulations (rapid, short, intermediate, long‑acting).
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Insulin human?
Recombinant human insulin used to replace deficient endogenous insulin in diabetes mellitus, controlling blood glucose levels.
What is Insulin human used for?
Insulin human is educationally associated with: Gestational diabetes management, Glycemic control in type 2 diabetes, Glycemic control in type 1 diabetes, Glycemic control in type 1 diabetes mellitus, Management of diabetic ketoacidosis (DKA), Perioperative glucose control, Hyperkalemia treatment, Glycemic control in type 2 diabetes mellitus. Educational only — not medical advice.
How is Insulin human administered?
Recorded routes of administration: Inhalation, Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Insulin human?
Reported adverse effects include: Hypokalemia, Hypoglycemia, Peripheral edema, Allergic reactions, Injection site reactions (lipohypertrophy, lipoatrophy), Anaphylaxis / systemic allergy, Injection‑site reactions, Weight gain. This list is not exhaustive — consult a qualified clinician.
Who should avoid Insulin human?
Recorded contraindications: Hypokalemia (uncorrected), Hypersensitivity to insulin human or excipients, Hypersensitivity to insulin or excipients, Hypoglycemia (active episode), Hypoglycemia. Consult a qualified clinician before use.