CA-074 methyl ester
Also known as: CA-074 Me, CA-074 methyl ester, CA-074ME, CA074 methyl ester, L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline methyl ester
Source CA-074 methyl ester at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
CA-074 methyl ester is a cell‑permeable pro‑drug of the selective cathepsin B inhibitor CA‑074, used primarily as a research tool to study cathepsin B‑dependent pathways.
Mechanism of Action
Irreversible covalent inhibition of cathepsin B via epoxysuccinyl warhead after intracellular ester hydrolysis
Routes of Administration
Goals & Uses
- Cathepsin B inhibitionTarget ValidationHigh
- Apoptosis and autophagy pathway researchCell Biology ResearchModerate
- Anti‑inflammatory researchPreclinicalModerate
- Cancer biology researchOncology ResearchModerate
- Neuroprotection researchNeuroscience ResearchModerate
- NLRP3 inflammasome suppressionInflammation ResearchModerate
- Cathepsin B inhibition (in vitro/in vivo research)Research Tool / Enzyme InhibitionHigh
Contraindications
- Human therapeutic useRegulatory/safetyHigh
Adverse Effects
- Cytotoxicity at high concentrationsIn Vitro ToxicityUncommon
- Off-target protease inhibitionPharmacologicalRare
- Unknown toxicitySystemicUnknown
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- Not for human administrationGeneral PopulationAbsolute
Regulatory Status
- European UnionUnapprovedNot authorized for clinical use
- United StatesUnapprovedResearch chemical only
- United KingdomUnapprovedResearch reagent only; not reviewed by MHRA.
Not approved for human therapeutic use; employed only in preclinical and in‑vitro studies.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is CA-074 methyl ester?
CA-074 methyl ester is a cell‑permeable pro‑drug of the selective cathepsin B inhibitor CA‑074, used primarily as a research tool to study cathepsin B‑dependent pathways.
What is CA-074 methyl ester used for?
CA-074 methyl ester is educationally associated with: Cathepsin B inhibition, Apoptosis and autophagy pathway research, Anti‑inflammatory research, Cancer biology research, Neuroprotection research, NLRP3 inflammasome suppression, Cathepsin B inhibition (in vitro/in vivo research). Educational only — not medical advice.
How is CA-074 methyl ester administered?
Recorded routes of administration: In Vitro (cell Culture Medium), Intraperitoneal, Intravenous, Oral (experimental), Subcutaneous.
What are the potential side effects of CA-074 methyl ester?
Reported adverse effects include: Cytotoxicity at high concentrations, Off-target protease inhibition, Unknown toxicity. This list is not exhaustive — consult a qualified clinician.
Who should avoid CA-074 methyl ester?
Recorded contraindications: Human therapeutic use. Consult a qualified clinician before use.