Carbetocin
Also known as: 1-butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin, Carbetocin, Carbetocin RTS, Duratocin, Oxytocin analogue, Pabal, RO 12-1685
Source Carbetocin at Peptiology
Save 10% with code PEPTI-BOSSRABBIT-10
Tapping Shop Now & Save 10% copies your 10% off code PEPTI-BOSSRABBIT-10 to your clipboard. Paste it at the Peptiology checkout to claim the discount.
Summary
Carbetocin is a synthetic peptide analogue of oxytocin used prophylactically to prevent postpartum hemorrhage by stimulating uterine contraction after delivery.
Mechanism of Action
Selective agonist of the oxytocin receptor, inducing uterine smooth muscle contraction and promoting hemostasis.
Routes of Administration
Goals & Uses
- Uterine atony managementObstetricsModerate
- Reduction of uterine atonyUterotonicHigh
- Prevention of postpartum hemorrhage after vaginal deliveryObstetric / HemostasisModerate
- Prevention of postpartum hemorrhageObstetricsHigh
- Non-pneumonic management of PPH in resource-limited settingsGlobal HealthModerate
- Prevention of postpartum hemorrhage after cesarean sectionObstetric / HemostasisHigh
Contraindications
- Severe cardiovascular disease (e.g., uncontrolled hypertension)CardiovascularModerate
- Known hypersensitivity to carbetocin or oxytocinAllergyHigh
- Use before delivery of the infantObstetricHigh
- Cardiovascular disease (severe)CardiovascularHigh
- Induction or augmentation of laborObstetricHigh
- Hypersensitivity to carbetocin or oxytocinAllergicHigh
- Hepatic or renal impairmentOrgan ImpairmentModerate
Adverse Effects
- HypertensionCardiovascularCommonHigh blood pressure
- HeadacheNeurologicCommonPain in the head or upper neck
- HypotensionCardiovascularCommonLow blood pressure
- Nausea/vomitingGastrointestinalCommon
- Tremor / chillsMusculoskeletal / SystemicUncommon
- FlushingVascularUncommonWarmth and redness of the skin
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
Drug Interactions
- Other uterotonics (e.g., oxytocin, misoprostol)Moderate
- Ergot alkaloids (e.g., methylergonovine)Moderate
- Vasopressors (e.g., epinephrine)Moderate
- Prostaglandins (e.g., misoprostol, dinoprostone)Moderate
- General anesthetics (halogenated agents)Moderate
Population Constraints
- Postpartum womenReproductiveAbsolute
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeAbsolute
- Women with severe cardiac diseaseCardiovascularRelative
- Severe cardiovascular diseaseCardiovascularRelative
- Pregnancy (before fetal delivery)ObstetricAbsolute
Regulatory Status
- European UnionApprovedApproved: Prevention of postpartum hemorrhage
- United StatesUnapprovedNot FDA‑approved; available only via clinical trial or compassionate use.
- United KingdomApprovedApproved: Prevention of postpartum hemorrhage
Approved in the EU, UK, and many other jurisdictions for postpartum hemorrhage; not FDA‑approved in the United States.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Carbetocin?
Carbetocin is a synthetic peptide analogue of oxytocin used prophylactically to prevent postpartum hemorrhage by stimulating uterine contraction after delivery.
What is Carbetocin used for?
Carbetocin is educationally associated with: Uterine atony management, Reduction of uterine atony, Prevention of postpartum hemorrhage after vaginal delivery, Prevention of postpartum hemorrhage, Non-pneumonic management of PPH in resource-limited settings, Prevention of postpartum hemorrhage after cesarean section. Educational only — not medical advice.
How is Carbetocin administered?
Recorded routes of administration: Intramuscular, Intravenous.
What are the potential side effects of Carbetocin?
Reported adverse effects include: Hypertension, Headache, Hypotension, Nausea/vomiting, Tremor / chills, Flushing, Tachycardia, Nausea. This list is not exhaustive — consult a qualified clinician.
Who should avoid Carbetocin?
Recorded contraindications: Severe cardiovascular disease (e.g., uncontrolled hypertension), Known hypersensitivity to carbetocin or oxytocin, Use before delivery of the infant, Cardiovascular disease (severe), Induction or augmentation of labor, Hypersensitivity to carbetocin or oxytocin, Hepatic or renal impairment. Consult a qualified clinician before use.