Lypressin
Also known as: 8-Lysine vasopressin, Diapid, LVP, Lypressin, Lysine vasopressin
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Summary
Lypressin (lysine vasopressin) is a synthetic nonapeptide analog of arginine vasopressin where Arg8 is replaced by Lys. It is used primarily as an antidiuretic to treat central diabetes insipidus and to control bleeding from esophageal varices in regions where it is approved.
Mechanism of Action
Agonist at V1a (vasoconstriction) and V2 (antidiuretic) vasopressin receptors, increasing water reabsorption in renal collecting ducts and causing peripheral vasoconstriction.
Routes of Administration
Goals & Uses
- Control of bleeding from esophageal varicesGastrointestinalModerate
- Treatment of central diabetes insipidusEndocrine / RenalModerate
- Management of central diabetes insipidusEndocrinologyModerate
- Reduction of polydipsiaSymptomatic ReliefModerate
- Reduction of polyuriaSymptomatic ReliefModerate
Contraindications
- Severe hyponatremiaElectrolyteHigh
- Known hypersensitivity to vasopressin analogsAllergyHigh
- Hypersensitivity to vasopressin or analoguesImmunologicHigh
- HypertensionCardiovascularModerate
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Unstable cardiovascular disease (e.g., recent MI)CardiovascularModerate
- Coronary artery diseaseCardiovascularHigh
- Nephrogenic diabetes insipidusRenalHigh
Adverse Effects
- Nasal congestion and rhinitisLocal / NasalCommon
- Hyponatremia / water intoxicationMetabolicRare
- HeadacheNeurologicCommonPain in the head or upper neck
- Myocardial ischemiaCardiovascularRare
- Abdominal crampsGastrointestinalUncommon
- Pallor and vasoconstrictionCardiovascularUncommon
- HyponatremiaElectrolyteCommon
- Angina pectorisCardiovascularRare
Drug Interactions
- Loop diureticsModerate
- Tricyclic antidepressantsLow
- NSAIDsLowMay increase renal risk in susceptible patients
- ChlorpropamideModerate
- Thiazide diureticsHigh
- LithiumModerate
- Vasodilators (e.g., nitroglycerin)Low
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- ElderlyAgeRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
- Patients with chronic renal diseaseRenal ImpairmentRelative
Regulatory Status
- European UnionApprovedApproved: central diabetes insipidus, esophageal variceal bleedingApproved in several EU member states under local brand names.
- JPApprovedApproved: central diabetes insipidusMarketed as Lypressin in Japan.
- United StatesUnapprovedNot FDA‑approved; considered investigational.
- United KingdomUnknownNot currently listed as an approved product in the UK; desmopressin is preferred.
Approved for medical use in several non‑US jurisdictions (e.g., Japan, some European countries). Not FDA‑approved in the United States; considered investigational there.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Lypressin?
Lypressin (lysine vasopressin) is a synthetic nonapeptide analog of arginine vasopressin where Arg8 is replaced by Lys. It is used primarily as an antidiuretic to treat central diabetes insipidus and to control bleeding from esophageal varices in regions where it is approved.
What is Lypressin used for?
Lypressin is educationally associated with: Control of bleeding from esophageal varices, Treatment of central diabetes insipidus, Management of central diabetes insipidus, Reduction of polydipsia, Reduction of polyuria. Educational only — not medical advice.
How is Lypressin administered?
Recorded routes of administration: Intramuscular, Intravenous, Nasal, Subcutaneous.
What are the potential side effects of Lypressin?
Reported adverse effects include: Nasal congestion and rhinitis, Hyponatremia / water intoxication, Headache, Myocardial ischemia, Abdominal cramps, Pallor and vasoconstriction, Hyponatremia, Angina pectoris. This list is not exhaustive — consult a qualified clinician.
Who should avoid Lypressin?
Recorded contraindications: Severe hyponatremia, Known hypersensitivity to vasopressin analogs, Hypersensitivity to vasopressin or analogues, Hypertension, Pregnancy, Unstable cardiovascular disease (e.g., recent MI), Coronary artery disease, Nephrogenic diabetes insipidus. Consult a qualified clinician before use.