Felypressin
Also known as: 2-Phe-8-Lys-vasopressin, Citanest with Octapressin, FEL, Felypressin, Octapressin, Phenylalanine-2-lysine-8-vasopressin, PLV-2, Vasopressin analog
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Summary
Felypressin is a peptide vasoconstrictor derived from snake venom, used primarily as an adjunct to local anesthetics to reduce bleeding and prolong anesthesia.
Mechanism of Action
Agonist at V1 vasopressin receptors causing peripheral vasoconstriction
Routes of Administration
Goals & Uses
- Prolongation of local anaesthesiaAnaesthesiaHigh
- Safe vasoconstriction in patients with cardiovascular contraindications to adrenalineCardiovascular Risk ReductionModerate
- Control intra‑operative bleedingSurgicalModerate
- Haemostasis in dental proceduresSurgical HaemostasisModerate
- Prolong local anesthetic effectAnestheticModerate
Contraindications
- Raynaud's disease / peripheral vascular diseaseVascularModerate
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Severe cardiovascular diseaseCardiovascularModerate
- Known hypersensitivity to felypressin or vasopressin analoguesAllergy / ImmunologyHigh
- Severe hypertensionCardiovascularHigh
Adverse Effects
- Hypersensitivity / allergic reactionImmunologicalRare
- Uterine contractionsObstetricUnknown
- HypertensionCardiovascularCommonHigh blood pressure
- HeadacheNeurologicCommonPain in the head or upper neck
- Local tissue ischaemiaVascularUncommon
- TachycardiaCardiovascularUncommonAbnormally fast heart rate
- Pallor at injection siteVascularCommon
- BradycardiaCardiovascularRare
Drug Interactions
- Other vasopressors / vasoconstrictorsModerate
- Tricyclic antidepressantsLow
- OxytocinHigh
- MAO inhibitorsHigh
- EpinephrineModerate
Population Constraints
- Elderly patients with cardiovascular diseaseCardiovascularRelative
- Pediatric patients (<12 y)AgeRelative
- Patients with renal impairmentOrgan ImpairmentRelative
- Paediatric patientsAgeRelative
- Patients with severe hypertensionCardiovascularRelative
- Pregnant womenReproductiveAbsolute
Regulatory Status
- European UnionUnapprovedNo centralized marketing authorization
- United StatesUnapprovedNot FDA‑approved; used off‑label in dentistry
- BRApprovedApproved: local dental anesthesiaApproved for use as vasoconstrictor in Brazil
- United KingdomApprovedApproved: Vasoconstrictor in dental local anaesthetic formulations (e.g., prilocaine 3% with felypressin 0.03 IU/mL)Available as Citanest with Octapressin; licensed for dental use.
Approved and in clinical use in the UK, EU, and various other countries as a component of dental local anaesthetic formulations. Not widely approved or marketed in the United States. Regulatory status varies by jurisdiction.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Felypressin?
Felypressin is a peptide vasoconstrictor derived from snake venom, used primarily as an adjunct to local anesthetics to reduce bleeding and prolong anesthesia.
What is Felypressin used for?
Felypressin is educationally associated with: Prolongation of local anaesthesia, Safe vasoconstriction in patients with cardiovascular contraindications to adrenaline, Control intra‑operative bleeding, Haemostasis in dental procedures, Prolong local anesthetic effect. Educational only — not medical advice.
How is Felypressin administered?
Recorded routes of administration: Intramuscular, Local Injection, Subcutaneous, Submucosal.
What are the potential side effects of Felypressin?
Reported adverse effects include: Hypersensitivity / allergic reaction, Uterine contractions, Hypertension, Headache, Local tissue ischaemia, Tachycardia, Pallor at injection site, Bradycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Felypressin?
Recorded contraindications: Raynaud's disease / peripheral vascular disease, Pregnancy, Severe cardiovascular disease, Known hypersensitivity to felypressin or vasopressin analogues, Severe hypertension. Consult a qualified clinician before use.