Chorionic Gonadotropin (Human)
Also known as: Choriogonadotropin alfa, Chorionic gonadotropin, hCG, Human chorionic gonadotrophin, Novarel, Ovidrel, Pregnyl
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Summary
Human chorionic gonadotropin (hCG) is a recombinant or purified hormone used to induce ovulation, support luteal phase, and treat male hypogonadism.
Mechanism of Action
Acts as an agonist at the luteinizing hormone (LH) receptor, stimulating steroidogenesis and supporting corpus luteum function.
Routes of Administration
Goals & Uses
- Ovulation induction / ART triggerReproductive EndocrinologyHigh
- Luteal phase supportFertilityHigh
- Ovulation inductionReproductive EndocrinologyHigh
- Corpus luteum support in ARTReproductive EndocrinologyHigh
- Male hypogonadism treatmentEndocrineModerate
- Testosterone optimization / fertility preservation during TRTMen's Health (off Label)Moderate
- Treatment of hypogonadotropic hypogonadism in malesEndocrinology / AndrologyHigh
- Cryptorchidism treatmentPediatric UrologyModerate
Contraindications
- Hypersensitivity to hCG or excipientsAllergy/ImmunologyHigh
- Pregnancy with molar gestationReproductiveHigh
- Ovarian hyperstimulation syndrome (OHSS) riskReproductive MedicineHigh
- Estrogen‑dependent tumorsOncologyModerate
- Primary gonadal failure (hypergonadotropic hypogonadism)EndocrinologyHigh
- Uncontrolled thyroid or adrenal dysfunctionEndocrinologyModerate
- Hormone-sensitive malignancies (e.g., prostate cancer, testicular germ cell tumors)OncologyHigh
- Precocious pubertyPediatric EndocrinologyHigh
- Uncontrolled hypertensionCardiovascularModerate
Adverse Effects
- Injection site reactionsLocalCommon
- Multiple gestationReproductiveUncommon
- HeadacheNeurologicCommonPain in the head or upper neck
- Thromboembolic eventsCardiovascularRare
- GynecomastiaEndocrineUncommon
- Injection site reactionLocalCommonRedness, swelling, itching, bruising, or pain at the injection site
- Ovarian hyperstimulation syndrome (OHSS)ReproductiveUncommon
- Gynecomastia (in males)EndocrineRare
Drug Interactions
- Exogenous testosterone (TRT)Low
- AnticoagulantsLowMonitor when nausea or vomiting affects intake
- Estrogen therapyModerate
- Aromatase inhibitors (e.g., anastrozole, letrozole)Low
- Clomiphene citrateLow
- GnRH agonists / antagonistsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Renal impairmentOrgan ImpairmentRelative
- Prepubertal childrenPediatricRelative
- Elderly (>65)AgeRelative
- Pediatric useAgeRelative
- Patients with history of thromboembolic diseaseCardiovascularRelative
Regulatory Status
- European UnionApprovedApproved: infertility, luteal phase supportMarketing authorisation granted.
- United StatesApprovedApproved: infertility, ovulation induction, testosterone stimulationPrescription only.
- United KingdomApprovedApproved: infertility, ovulation inductionAvailable via specialist prescription.
FDA‑approved for infertility, ovulation induction, and as a testosterone‑stimulating agent; also approved in EU and UK for similar indications.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Chorionic Gonadotropin (Human)?
Human chorionic gonadotropin (hCG) is a recombinant or purified hormone used to induce ovulation, support luteal phase, and treat male hypogonadism.
What is Chorionic Gonadotropin (Human) used for?
Chorionic Gonadotropin (Human) is educationally associated with: Ovulation induction / ART trigger, Luteal phase support, Ovulation induction, Corpus luteum support in ART, Male hypogonadism treatment, Testosterone optimization / fertility preservation during TRT, Treatment of hypogonadotropic hypogonadism in males, Cryptorchidism treatment. Educational only — not medical advice.
How is Chorionic Gonadotropin (Human) administered?
Recorded routes of administration: Intramuscular, Intravenous, Subcutaneous.
What are the potential side effects of Chorionic Gonadotropin (Human)?
Reported adverse effects include: Injection site reactions, Multiple gestation, Headache, Thromboembolic events, Gynecomastia, Injection site reaction, Ovarian hyperstimulation syndrome (OHSS), Gynecomastia (in males). This list is not exhaustive — consult a qualified clinician.
Who should avoid Chorionic Gonadotropin (Human)?
Recorded contraindications: Hypersensitivity to hCG or excipients, Pregnancy with molar gestation, Ovarian hyperstimulation syndrome (OHSS) risk, Estrogen‑dependent tumors, Primary gonadal failure (hypergonadotropic hypogonadism), Uncontrolled thyroid or adrenal dysfunction, Hormone-sensitive malignancies (e.g., prostate cancer, testicular germ cell tumors), Precocious puberty, Uncontrolled hypertension. Consult a qualified clinician before use.