Thyrotropin
Also known as: recombinant human TSH, rhTSH, Thyrogen, Thyroid-stimulating hormone, Thyrotropin alfa, TSH
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Summary
Thyrotropin (TSH) is a heterodimeric glycoprotein hormone (alpha and beta subunits) secreted by the anterior pituitary. Recombinant human TSH (rhTSH) is approved for diagnostic stimulation of thyroid tissue in differentiated thyroid cancer and for radioiodine ablation preparation.
Mechanism of Action
Binds TSH receptor (GPCR) on thyroid follicular cells, activating cAMP pathway to stimulate thyroid hormone synthesis and release
Routes of Administration
Goals & Uses
- Thyroglobulin surveillance in thyroid cancerOncology / DiagnosticsHigh
- Stimulation of radioiodine uptake in metastatic thyroid cancerOncologyModerate
- Radioiodine remnant ablation in differentiated thyroid cancerOncologyHigh
- Stimulate thyroid hormone productionTherapeuticHigh
- Diagnostic radioiodine scintigraphyDiagnosticsHigh
- Diagnostic stimulation of thyroid tissueDiagnosticHigh
Contraindications
- Hypersensitivity to recombinant TSHAllergyHigh
- Large thyroid remnants with risk of swelling causing airway compromiseStructural / AnatomicalHigh
- PregnancyPopulationModeratePotential fetal risk or insufficient safety data
- Pediatric use (children under 16)PopulationModerate
- Hypersensitivity to thyrotropin alfa or excipientsAllergy/ImmunologyHigh
Adverse Effects
- Injection site painLocalCommonPain at the injection site
- Hypersensitivity/anaphylaxisImmunologicalRare
- HeadacheNeurologicCommonPain in the head or upper neck
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- FatigueGeneralCommonLow energy or tiredness
- VomitingGastrointestinalUncommonForceful expulsion of stomach contents
- Neurological deterioration / stroke-like symptomsNeurologicalRare
- FeverSystemicUncommonElevated body temperature
Drug Interactions
- LevothyroxineModerate
- Radioiodine (I-131)Low
Population Constraints
- PregnancyReproductive SafetyRelative
- Renal impairmentOrgan ImpairmentRelative
- Pediatric patientsAgeRelative
- Patients with known CNS metastasesOncologyRelative
- Elderly patientsAgeRelative
- Pregnant womenReproductiveRelative
Regulatory Status
- European UnionApprovedApproved: Diagnostic stimulation of thyroid tissue in differentiated thyroid cancer
- United StatesApprovedApproved: Diagnostic stimulation of thyroid tissue in differentiated thyroid cancer, Preparation for radioiodine ablationMarketed as Thyrogen
- United KingdomApprovedApproved: Diagnostic stimulation of thyroid tissue in differentiated thyroid cancer
Approved as Thyrogen (rhTSH) for diagnostic use in the US, EU, and UK. Not indicated for routine thyroid hormone replacement.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Thyrotropin?
Thyrotropin (TSH) is a heterodimeric glycoprotein hormone (alpha and beta subunits) secreted by the anterior pituitary. Recombinant human TSH (rhTSH) is approved for diagnostic stimulation of thyroid tissue in differentiated thyroid cancer and for radioiodine ablation preparation.
What is Thyrotropin used for?
Thyrotropin is educationally associated with: Thyroglobulin surveillance in thyroid cancer, Stimulation of radioiodine uptake in metastatic thyroid cancer, Radioiodine remnant ablation in differentiated thyroid cancer, Stimulate thyroid hormone production, Diagnostic radioiodine scintigraphy, Diagnostic stimulation of thyroid tissue. Educational only — not medical advice.
How is Thyrotropin administered?
Recorded routes of administration: Intramuscular, Subcutaneous.
What are the potential side effects of Thyrotropin?
Reported adverse effects include: Injection site pain, Hypersensitivity/anaphylaxis, Headache, Nausea, Fatigue, Vomiting, Neurological deterioration / stroke-like symptoms, Fever. This list is not exhaustive — consult a qualified clinician.
Who should avoid Thyrotropin?
Recorded contraindications: Hypersensitivity to recombinant TSH, Large thyroid remnants with risk of swelling causing airway compromise, Pregnancy, Pediatric use (children under 16), Hypersensitivity to thyrotropin alfa or excipients. Consult a qualified clinician before use.