Secretin human
Also known as: ChiRhoStim, Human secretin, SCT, SEC, SecreFlo, Secretin
Source Secretin human at Peptiology
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Summary
Synthetic human secretin is a 27‑amino‑acid peptide used primarily for diagnostic pancreatic function tests and secretin‑enhanced MRCP; it stimulates pancreatic exocrine secretion via the secretin receptor.
Mechanism of Action
Activates the secretin G‑protein‑coupled receptor, stimulating adenylate cyclase → ↑cAMP → pancreatic ductal bicarbonate and water secretion; also modulates bile flow and gastric acid secretion.
Routes of Administration
Goals & Uses
- Pancreatic function testingDiagnosticHigh
- Pancreatic exocrine function testingDiagnosticHigh
- Autism spectrum disorder (investigational)Neurological / InvestigationalLow
- Diagnosis of gastrinoma (Zollinger-Ellison syndrome)DiagnosticHigh
- Facilitation of ERCPDiagnostic / ProceduralHigh
- Magnetic resonance cholangiopancreatography (MRCP) enhancementDiagnostic / ImagingModerate
- Secretin‑enhanced MRCPDiagnostic ImagingModerate
Contraindications
- Hypersensitivity to secretin or excipientsAllergyHigh
- Vagotomy or inflammatory bowel disease affecting duodenumGastrointestinal / SurgicalModerate
- Severe renal impairmentOrganModerateKidney function concerns
- Acute pancreatitisGastrointestinalHigh
- Hypersensitivity to secretin or any excipientsAllergy / ImmunologicHigh
Adverse Effects
- Abdominal discomfortGastrointestinalUncommon
- Anaphylaxis / hypersensitivityImmunologicRare
- HeadacheNeurologicUncommonPain in the head or upper neck
- HypotensionCardiovascularRareLow blood pressure
- FlushingVascularCommonWarmth and redness of the skin
- NauseaGastrointestinalCommonFeeling of sickness or urge to vomit
- Abdominal discomfort / crampingGastrointestinalUncommon
- BradycardiaCardiovascularRare
Drug Interactions
- Proton pump inhibitors (PPIs)Low
- Anticholinergics (e.g., atropine)Moderate
- Other secretagogues (e.g., CCK, gastrin)Moderate
- H2-receptor antagonistsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Pediatric (<2 years)AgeRelative
- Patients with known allergy to porcine secretinAllergy / ImmunologicRelative
- Renal or hepatic impairmentOrgan DysfunctionRelative
Regulatory Status
- European UnionApprovedApproved: Pancreatic function testingAvailable in several member states.
- United StatesApprovedApproved: Pancreatic function testing, Secretin‑enhanced MRCPPrescription‑only injectable.
- United KingdomUnknownAvailability and approval status in the UK post-Brexit is not well-documented for human synthetic secretin specifically.
Approved by the FDA as ChiRhoStim (human secretin) for diagnostic use. Also used to aid in the diagnosis of gastrinoma (Zollinger-Ellison syndrome) via the secretin stimulation test.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Secretin human?
Synthetic human secretin is a 27‑amino‑acid peptide used primarily for diagnostic pancreatic function tests and secretin‑enhanced MRCP; it stimulates pancreatic exocrine secretion via the secretin receptor.
What is Secretin human used for?
Secretin human is educationally associated with: Pancreatic function testing, Pancreatic exocrine function testing, Autism spectrum disorder (investigational), Diagnosis of gastrinoma (Zollinger-Ellison syndrome), Facilitation of ERCP, Magnetic resonance cholangiopancreatography (MRCP) enhancement, Secretin‑enhanced MRCP. Educational only — not medical advice.
How is Secretin human administered?
Recorded routes of administration: Intravenous.
What are the potential side effects of Secretin human?
Reported adverse effects include: Abdominal discomfort, Anaphylaxis / hypersensitivity, Headache, Hypotension, Flushing, Nausea, Abdominal discomfort / cramping, Bradycardia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Secretin human?
Recorded contraindications: Hypersensitivity to secretin or excipients, Vagotomy or inflammatory bowel disease affecting duodenum, Severe renal impairment, Acute pancreatitis, Hypersensitivity to secretin or any excipients. Consult a qualified clinician before use.