Cintredekin besudotox
Also known as: Cintredekin, cintredekin besudotox, IL13-PE38QQR
Source Cintredekin besudotox at Peptiology
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Summary
Cintredekin besudotox is an investigational recombinant fusion protein comprising interleukin‑13 and a truncated Pseudomonas exotoxin (PE38). It is administered by convection‑enhanced intracerebral infusion to target IL‑13Rα2‑expressing glioblastoma.
Mechanism of Action
Binds IL-13Rα2 on tumor cells, internalizes, and the exotoxin domain ADP‑ribosylates EF‑2 halting protein synthesis and inducing cell death
Routes of Administration
Goals & Uses
- Treatment of recurrent glioblastomaOncologyModerate
Contraindications
- Known hypersensitivity to Pseudomonas exotoxinAllergyHigh
Adverse Effects
- HeadacheNeurologicCommonPain in the head or upper neck
- Intracranial hemorrhageNeurologicalUncommon
- Cerebral edemaNeurologicalCommon
Drug Interactions
- CorticosteroidsLow
Population Constraints
- Pediatric patientsAgeRelative
Regulatory Status
- European UnionInvestigationalClinical trial status; no marketing authorization
- United StatesInvestigationalInvestigational New Drug (IND) application; not FDA‑approved
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Cintredekin besudotox?
Cintredekin besudotox is an investigational recombinant fusion protein comprising interleukin‑13 and a truncated Pseudomonas exotoxin (PE38). It is administered by convection‑enhanced intracerebral infusion to target IL‑13Rα2‑expressing glioblastoma.
What is Cintredekin besudotox used for?
Cintredekin besudotox is educationally associated with: Treatment of recurrent glioblastoma. Educational only — not medical advice.
How is Cintredekin besudotox administered?
Recorded routes of administration: Intracerebral Infusion (convection‑enhanced Delivery).
What are the potential side effects of Cintredekin besudotox?
Reported adverse effects include: Headache, Intracranial hemorrhage, Cerebral edema. This list is not exhaustive — consult a qualified clinician.
Who should avoid Cintredekin besudotox?
Recorded contraindications: Known hypersensitivity to Pseudomonas exotoxin. Consult a qualified clinician before use.