Glutathione disulfide
Also known as: GSH disulfide, GSSG, L-Glutathione oxidized, Oxidized glutathione
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Summary
Glutathione disulfide (GSSG) is the oxidized dimeric form of the endogenous tripeptide glutathione, linked by a disulfide bond between two cysteine residues.
Mechanism of Action
acts as cellular redox buffer; oxidized form can be reduced back to glutathione, participates in antioxidant defenses
Routes of Administration
Goals & Uses
- Redox status biomarkerResearch / DiagnosticsHigh
- Oxidative stress researchResearch ToolHigh
- Antioxidant system supportCellular ProtectionLow
- Protein glutathionylation modulationRedox SignalingModerate
- oxidative stress assessmentDiagnosticModerate
Contraindications
- Known hypersensitivity to glutathione compoundsAllergyHigh
- High systemic GSSG levels (severe oxidative stress)PathophysiologyModerate
Adverse Effects
- Injection site reactionsLocalUncommon
- NauseaGastrointestinalUncommonFeeling of sickness or urge to vomit
- Pro-oxidant effects at high concentrationsOxidative ToxicityUnknown
Drug Interactions
- Glutathione reductase inhibitorsModerate
- Cisplatin and platinum-based chemotherapeuticsModerate
Population Constraints
- PregnancyReproductive SafetyRelative
- Glucose-6-phosphate dehydrogenase (G6PD) deficiencyGenetic / MetabolicRelative
- NeonatesPediatricRelative
Regulatory Status
- European UnionUnapprovedNot EMA-approved; no marketing authorization for therapeutic use.
- United StatesUnapprovedNot an FDA‑approved drug
- United KingdomUnapprovedNot MHRA-approved as a medicinal product.
Not approved as a therapeutic agent; used as a biochemical marker of oxidative stress in research settings.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Glutathione disulfide?
Glutathione disulfide (GSSG) is the oxidized dimeric form of the endogenous tripeptide glutathione, linked by a disulfide bond between two cysteine residues.
What is Glutathione disulfide used for?
Glutathione disulfide is educationally associated with: Redox status biomarker, Oxidative stress research, Antioxidant system support, Protein glutathionylation modulation, oxidative stress assessment. Educational only — not medical advice.
How is Glutathione disulfide administered?
Recorded routes of administration: Intravenous, Subcutaneous, Topical.
What are the potential side effects of Glutathione disulfide?
Reported adverse effects include: Injection site reactions, Nausea, Pro-oxidant effects at high concentrations. This list is not exhaustive — consult a qualified clinician.
Who should avoid Glutathione disulfide?
Recorded contraindications: Known hypersensitivity to glutathione compounds, High systemic GSSG levels (severe oxidative stress). Consult a qualified clinician before use.