Malacidin A
Also known as: Calcium-Dependent Antibiotic from soil metagenome, Malacidin, Malacidin A
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Summary
Malacidin A is a calcium‑dependent cyclic lipopeptide antibiotic identified from soil metagenomes. It shows potent activity against Gram‑positive pathogens, including MRSA, by binding calcium and disrupting bacterial membranes. It remains a research compound with no clinical approval.
Mechanism of Action
Calcium-dependent binding to bacterial membrane lipids causing membrane disruption and bacterial cell death
Routes of Administration
No administration routes recorded yet.
Goals & Uses
- Treatment of multidrug-resistant Gram-positive infectionsAntimicrobial / Infectious DiseaseLow
- Treatment of MRSA infectionsAntimicrobialLow
- Overcoming antibiotic resistanceAntimicrobial ResearchLow
- Develop novel antibiotics for resistant Gram‑positive infectionsAntibacterial TherapyModerate
Contraindications
- Human useClinicalHigh
Adverse Effects
- Unknown adverse effectsGeneralUnknown
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- All human populationsGeneralAbsolute
Regulatory Status
- European UnionUnapprovedNo EMA assessment; research use only.
- United StatesUnapprovedNo FDA evaluation; investigational only.
- United KingdomUnapprovedNot licensed for clinical use.
Investigational; not approved for human use in any jurisdiction.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Malacidin A?
Malacidin A is a calcium‑dependent cyclic lipopeptide antibiotic identified from soil metagenomes. It shows potent activity against Gram‑positive pathogens, including MRSA, by binding calcium and disrupting bacterial membranes. It remains a research compound with no clinical approval.
What is Malacidin A used for?
Malacidin A is educationally associated with: Treatment of multidrug-resistant Gram-positive infections, Treatment of MRSA infections, Overcoming antibiotic resistance, Develop novel antibiotics for resistant Gram‑positive infections. Educational only — not medical advice.
What are the potential side effects of Malacidin A?
Reported adverse effects include: Unknown adverse effects. This list is not exhaustive — consult a qualified clinician.
Who should avoid Malacidin A?
Recorded contraindications: Human use. Consult a qualified clinician before use.