Z-Pro-Prolinal
Also known as: Cbz-Pro-Prolinal, N-benzyloxycarbonyl-L-prolyl-L-prolinal, Z-Pro-Prolinal, ZPP
Source Z-Pro-Prolinal at Peptiology
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Summary
Z‑Pro‑Prolinal (ZPP) is a synthetic benzyloxycarbonyl‑prolyl‑prolinal aldehyde used as a selective inhibitor of prolyl endopeptidase in biochemical and preclinical studies.
Mechanism of Action
Covalent reversible inhibition of prolyl endopeptidase (PEP) via hemiacetal formation with the active‑site serine residue
Routes of Administration
Goals & Uses
- Investigate role of prolyl endopeptidase in cognitionResearchModerate
- Neuropeptide metabolism researchNeuroscience / BiochemistryModerate
- Psychiatric disorder modelingPreclinical Disease ModelingLow
- Validate PEP as therapeutic targetResearchModerate
- Prolyl endopeptidase inhibitionEnzyme Inhibition / Pharmacological ToolHigh
- Cognitive and memory researchNeuropharmacologyModerate
Contraindications
- Human clinical useRegulatoryHigh
Adverse Effects
- Off-target protease inhibitionPharmacologicalUnknown
- Behavioral alterationsNeurological (preclinical)Unknown
- UnknownUnknownUnknown
Drug Interactions
No drug interactions recorded yet.
Population Constraints
- All human populationsGeneralAbsolute
Regulatory Status
- European UnionUnapprovedResearch chemical only; no CTA filed.
- United StatesUnapprovedResearch chemical only; no IND filed.
- United KingdomUnapprovedResearch chemical only; no clinical authorisation.
No regulatory approval in any jurisdiction. Used exclusively as a biochemical research tool. Not an approved drug or investigational medicinal product under IND/CTA.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Z-Pro-Prolinal?
Z‑Pro‑Prolinal (ZPP) is a synthetic benzyloxycarbonyl‑prolyl‑prolinal aldehyde used as a selective inhibitor of prolyl endopeptidase in biochemical and preclinical studies.
What is Z-Pro-Prolinal used for?
Z-Pro-Prolinal is educationally associated with: Investigate role of prolyl endopeptidase in cognition, Neuropeptide metabolism research, Psychiatric disorder modeling, Validate PEP as therapeutic target, Prolyl endopeptidase inhibition, Cognitive and memory research. Educational only — not medical advice.
How is Z-Pro-Prolinal administered?
Recorded routes of administration: Intracerebroventricular, Intraperitoneal, Intravenous.
What are the potential side effects of Z-Pro-Prolinal?
Reported adverse effects include: Off-target protease inhibition, Behavioral alterations, Unknown. This list is not exhaustive — consult a qualified clinician.
Who should avoid Z-Pro-Prolinal?
Recorded contraindications: Human clinical use. Consult a qualified clinician before use.