Arginine glutamate
Also known as: Arginine glutamate salt, Arginini glutamas, Glutargin, L-Arginine L-Glutamate
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Summary
Arginine glutamate is a salt of L-arginine and L-glutamic acid used primarily as a hepatoprotective and detoxifying agent. It is used clinically for hepatic encephalopathy, ammonia toxicity, and as a nutritional supplement in some jurisdictions. It promotes ammonia metabolism through the urea cycle and supports nitrogen homeostasis.
Mechanism of Action
Arginine serves as a precursor to nitric oxide via nitric oxide synthase, supporting vasodilation and ammonia detoxification via the urea cycle; glutamate participates in nitrogen metabolism, neurotransmission, and protein synthesis. Together they provide synergistic support for hepatic ammonia clearance and nitrogen balance.
Routes of Administration
Goals & Uses
- Nitrogen balance supportNutritional SupportLow
- Liver protection / hepatoprotectionHepatologyLow
- Hepatic encephalopathy managementHepatologyModerate
- Nitric oxide precursor supportCardiovascularLow
- Ammonia detoxificationMetabolic SupportModerate
Contraindications
- Severe renal failureRenal ImpairmentHigh
- Severe metabolic alkalosisElectrolyte/acid Base DisorderModerate
- HyperargininemiaMetabolic DisorderHigh
- Known hypersensitivity to arginine or glutamateAllergyHigh
Adverse Effects
- Injection site reactionsLocalUncommon
- HypotensionCardiovascularUncommonLow blood pressure
- FlushingVascularUncommonWarmth and redness of the skin
- Nausea and vomitingGastrointestinalCommon
- HyperkalemiaElectrolyte ImbalanceUncommon
Drug Interactions
- Antihypertensive agentsLow
- Potassium-sparing diuretics / ACE inhibitorsModerate
- Lysine supplementsLow
Population Constraints
- PregnancyReproductive SafetyRelative
- Pediatric patientsAgeRelative
- Patients with active herpes simplex infectionInfectious DiseaseRelative
Regulatory Status
- European UnionApprovedApproved: Hepatic encephalopathy, Hyperammonemia supportApproved in some EU member states (e.g., Ukraine, Romania) as a pharmaceutical; not centrally approved by EMA.
- United StatesUnapprovedNot FDA-approved as a drug. Constituent amino acids are available as dietary supplements (GRAS status).
- United KingdomUnknownNo specific MHRA approval identified for arginine glutamate as a pharmaceutical entity.
Approved in several European and Asian countries as a parenteral or oral hepatoprotective agent. Not independently FDA-approved in the United States as a drug, though its constituent amino acids are GRAS. Available as a pharmaceutical product (e.g., Glutargin) in Ukraine and some Eastern European countries.
Evidence & Sources
No sources recorded yet.
Frequently Asked Questions
What is Arginine glutamate?
Arginine glutamate is a salt of L-arginine and L-glutamic acid used primarily as a hepatoprotective and detoxifying agent. It is used clinically for hepatic encephalopathy, ammonia toxicity, and as a nutritional supplement in some jurisdictions. It promotes ammonia metabolism through the urea cycle and supports nitrogen homeostasis.
What is Arginine glutamate used for?
Arginine glutamate is educationally associated with: Nitrogen balance support, Liver protection / hepatoprotection, Hepatic encephalopathy management, Nitric oxide precursor support, Ammonia detoxification. Educational only — not medical advice.
How is Arginine glutamate administered?
Recorded routes of administration: Intravenous, Oral.
What are the potential side effects of Arginine glutamate?
Reported adverse effects include: Injection site reactions, Hypotension, Flushing, Nausea and vomiting, Hyperkalemia. This list is not exhaustive — consult a qualified clinician.
Who should avoid Arginine glutamate?
Recorded contraindications: Severe renal failure, Severe metabolic alkalosis, Hyperargininemia, Known hypersensitivity to arginine or glutamate. Consult a qualified clinician before use.